Penicillin

Question 1

Explain the mechanism of action

Answer 1

inhibit cell wall synthesis

Question 2

Which group does penicillin belong to?

Answer 2

Beta Lactam

Question 3

3 main types of penicillin?

Answer 3

Penicillin G (IV)
Penicillin V (oral)
Benzylpenicillin (IM)

Question 4

What type of bacteria does penicillin act against?

Answer 4

1. Gram + organisms

- streptococci, staphylocci

Question 5

What kind of diseases to Gram + organisms cause?

Answer 5

1. Skin infection - cellulitis / wound infection
2. Bone infection - oestemyelitis
3. Resp tract infection - pneumonia

Question 6

Tx of cellulitis

Answer 6

Flucoxicillin ( Clarithromycin if allergic)

Question 7

Tx of infective exacerbation of COPD

Answer 7

Amoxicillin ( Doxycycline if allergic)

Question 8

Tx of Pneumonia

Answer 8

Amoxicillin + Macrolide

Question 9

Are penicillins bacteriostatic or bactericidal?

Answer 9

Bactericidal

Question 10

How are penicillins excreted?

Answer 10

Via the kidneys

Question 11

Are penicillins safe in pregnancy?

Answer 11

Yes

Question 12

Which antibiotic contains a beta-lactam ring in the nucleus?

Answer 12

Penecillins

Cephalosporins

Question 13

Which bacteria is flucloxacillin useful for?

Answer 13

Staphylococci and streptococci only

Question 14

Which antibiotic is the drug of choice in staph aureus infection?

Answer 14

Flucloxacillin

Question 15

What is co-amoxiclav a combination of?

Answer 15

Amoxicillin and cluvulanic acid