Trimethoprim Flashcards
1
Q
Indications
A
- UTI
2 As co-trimoxazole (trimethoprim + sulfamethoxazole) is used for pneumocyctis pneumonia
2
Q
Mechanism of action
A
Inhibition of bacterial folate synthesis (bacteriostatic)
3
Q
Adverse effects
A
GI upset
Skin rash
4
Q
Warnings
A
Contraindicated in the first trimester of pregnancy - as a folate antagonist it can cause neural tube defects
5
Q
Interactions
A
Use with potassium-elevating drugs predisposes to hypokalaemia
Can enhance the anticoagulant effect of warfarin by killing the bacteria that synthesise vit K.
6
Q
Prescribing
A
PO
7
Q
Administration
A
Explain that the aim is to get rid of infection.
