Thrombolytics Flashcards
1
Q
Indications
A
- Acute ischaemic stroke
- In acute ST elevation myocardial infarction
- For massive pulmonary embolism with haemodynamic instability
2
Q
Mechanism of action
A
Catalyse the conversion of plasminogen to plasmin, which acts to dissolve fibrinous clots and re-canalise occluded vessels.
3
Q
Adverse effects
A
Nausea
Vomiting
Bruising
4
Q
Warnings
A
Contraindicated in recent haemmorhage, recent trauma or surgery, bleeding disorders, severe hypertension.
Intracranial haemorrhage must be ruled out via CT before treatment.
5
Q
Interactions
A
Increased risk of bleeding when used with other anti-coagulants.
6
Q
Prescribing
A
Should only be used by those experienced in their use.
7
Q
Monitoring
A
Pts should be monitored in an HDU/ICU setting.
