Potassium sparing diuretics

Question 1

Indications

Answer 1

As part of combination therapy

For the treatment of hypokalaemia arising from loop- or thiazide diuretics

Question 2

Mechanism of action

Answer 2

Amiloride - acts on distal convoluted tubule where it inhibits the uptake of sodium (and therefore water), causing sodium and water loss and retention of potassium.

Question 3

Adverse effects

Answer 3

GI upset
Dizziness
Hypotension

Question 4

Warnings

Answer 4

Avoid in severe renal impairment and hyperkalaemia

Question 5

Interactions

Answer 5

Do not use with other k-elevating drugs

Question 6

Prescription

Answer 6

State strength of tablet if using as a combination therapy.

Question 7

Administration

Answer 7

It is best to take diuretic tablets in the morning, to minimise nocturia.

Question 8

Communication

Answer 8

Explain that their potassium level is low because of the water tablet they are already taking. You are now offering to change to a different water tablet, which contains another medicine that will hopefully prevent the loss of potassium

Question 9

Monitoring

Answer 9

Symptomatic