Proton pump inhibitors Flashcards
1
Q
Indications
A
- Prevention and treatment of peptic ulcer disease inc. NSAID-assoc. ulcers
2
Q
Mechanism of action
A
Reduce gastric secretions
Irreversibly inhibit the H+/K+ ATPase in gastric parietal cells
3
Q
Adverse effects
A
GI disturbances
Headache
Increased risk of GI infection
Hyomagnesia (long-term use)
4
Q
Warnings
A
May disguise symptoms of gastric cancer
Might increase risk of fracture with long term use
5
Q
Interactions
A
May reduce anti-platelet effect of clopidogrel
6
Q
Prescription
A
Oral and injectable.
Generally the lowest effective dose should be used for the shortest time possible.
7
Q
Administration
A
Oral preparations can be taken with food or on an empty stomach.
8
Q
Communication
A
Explain that you are prescribing medication to reduce the production of stomach acid.
9
Q
Monitoring
A
Response to treatment
10
Q
Cost
A
Inexpensive
