H2 antagonists

Question 1

Common indications.

Answer 1

1. Peptic ulcer disease: for treatment and prevention of gastric and duodenal ulcers and NSAID-associated ulcers, although PPIs are more effective
2. Gastro-oesophageal reflux disease (GORD) and dyspepsia for relief of symptoms.

Question 2

Mechanism of action

Answer 2

Histamine H2-receptor antagonist - reduce gastric acid secretion by proton pump, which is regulated (in part) by H2 receptors.

Question 3

Important adverse effects

Answer 3

Generally few side-effects

Question 4

Warnings

Answer 4

Renal excretion - does should be reduced in renal impairment

Can disguise the symptoms of gastric cancer.

Question 5

Interactions

Answer 5

None major