Triglycerides Metabolism Flashcards
Two methods by which triglycerides can be obtained
Exogenous (from diet)
Endogenous (de novo synthesis)
Two primary areas in the body of triglyceride synthesis
Liver and adipose tissue
Triglycerides are formed from the combination of which two molecule
Glycerol-3-phosphate and 3 fatty acyl acid (fatty acid)
What is the form in which triglycerides are sent to extra-hepatic tissues from the liver
VLDL
What are are 2 sources of glycerol 3-P for triglyceride synthesis
- Reduction of dihydroxyacetone phosphate
2. Phosphorylation of free glycerol
Where does free glycerol come from in the liver for triglyceride metabolism
VLDL metabolism
Glycerol kinase control which reaction
Conversion of glycerol of glycerol-3-P
Which enzyme converts glucose to DHAP
Glycerol-3-P dehydrogenase
Which organ is glycerol kinase only found in
Liver
Which tissue depends solely on glucose to make trigycerides
Adipose tissue
Which transporters do adipose tissues relay heavily on (to bring in glucose)
GLUT 4
How does the amount of carbs in the diet relate to triglyceride synthesis
carbs are broken down to glucose which are then used by both liver and adipose tissue to make DHAP then Glycerol-3-P then triglycerides
What enzyme acts on transported triglycerides
Lipoprotein lipase which breaks them down to glycerol and free fatty acids
Two fates of free fatty acids
- Stored as triglycerides in adipose
2. Oxidized to produce energy in heart and muscle
Two tissues where triglycerides can be stored
white adipose tissue as fat and a little in the liver
