Triacylglycerol Flashcards

0
Q

Increased synthesis and storage of TAG could lead to

A

Obesity

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1
Q

Chief storage form of energy in thebody

A

TAG

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2
Q

Old man face
Skin and Bony Appearance

Due to deprivation of calorie

A

Marasmus

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3
Q

In 70 kgman, how many kilocalories

A

135, 000 kilocalories

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4
Q

Normal body mass index

A

18-24

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5
Q

Grade 1 obesity

A

25-30

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6
Q

Clinical obesity

A

Greater than 30. Mass index

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7
Q

Grade 3 obesity

A

Morbid obesity

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8
Q

Lipoproteins that have TAG as there lipid component

A

Chylomicron

VLDL

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9
Q

Cause of abnormal lipoprotein disorders

A

Impaired metabolism of TAGs
Deficiency of Lipoprotein Lipase
Disease associated with obesity

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10
Q

4Fs of gall bladder disease

A

Fat
Female
Forty
Fertile

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22
Q

Location of TAG synthesis

A

SER

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23
Q

Three organs that are active in TAG synthesis

A

Adipose tissue
Liver
Intestines

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24
Q

TAG synthesis reaction 1

A

Activation of Fatty acids

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25
Q

TAG synthesis

Reaction 1 activation of Fatty acids

A

Fatty acids + ATP to

Fatty acids CoA + AMP + PPI

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26
Q

TAG synthesis

Reaction 1 enzyme

A

Thiokinase/ Fatty Acyl CoA

27
Q

Magiging activated ang fatty acid by incorporating it to

A

CoA in the presence of thiokinaseor. Fatty acyl synthetase

Eg. Palmitic acid when activated it becomes palmitoyl CoA

28
Q

TAG synthesis

Reaction 2

A

Phosphorylation of Glycerol

29
Q

TAG synthesis reaction 2 Phosphorylation of Glycerol

A

Glycerol to

Glycerol 3 phosphate

30
Q

TAG synthesis

Reaction 2 enzyme

A

Glycerokinase

31
Q

Low activity or absent sa adipose tissue and skeletal muscle ang Glycerokinase, so saan nakukuha ang Ito?

A

Dihydroxyacetone phosphate

32
Q

TAG synthesis

Reaction 3

A

Combination of reactants

33
Q

TAG synthesis

Reaction 3 combination of reactants

A

Glycerol 3 Phosphate (from reaction 2) + 2 Fatty Acyl CoA (from reaction1) to

Phosphatidic acid

34
Q

TAG synthesis

Reaction 3 enzyme

A

Acyl Transferase

35
Q

TAG synthesis reaction 3

2 fatty acyl CoA attaches to ____ and ____ of the Glycerol 3 Phosphate molecule

A

C1 and C2

36
Q

TAG synthesis

Reaction 3

Parent compound for all glycerolphosphatide also phosphoglyceride

A

Phosphatidic acid

37
Q

TAG synthesis

Reaction 3

R1 and R2 fatty acids esterified via __________. 2nd carbon via ________.

A

Primary ester bond

Secondary ester bond

38
Q

Phosphatidic acid is intermediate not only in TAG synhtesis but also in

A

Phospholipid synthesis

39
Q

TAG synthesis

Reaction 4

A

Phosphatidic Acid to

1,2 Diacylglycerol

40
Q

TAG synthesis

Reaction 4

Enzyme

A

Phosphatase

41
Q

TAG synthesis

Reaction 4
Phosphatase removes the _______ at the C3 of Glycerol molecule

A

Phosphoric Acid Residue

42
Q

TAG synthesis

Reaction 5

A

1,2 Diacylglycerol + fatty Acyl CoA to

TAG

43
Q

TAG synthesis

Reaction 5 enzyme

A

Acyl Transferase

44
Q

Ratelimiting/Commited step

A

Reaction 5

45
Q

Next that incorporates the fatty acid into 1,2 diacylglycerol

A

Fatty Acyl Glycerol