Lipd Metabolism Fat Absorption Flashcards
Absorption of long chain fatty acid and 2 monoacylglycerol
Longchain FA + 2 MAG combine with bile salts Bile salt micelle Release FA and 2MAG in intestinal cells Absorbed in intestinal cells Then FA and 2 MAG react with each other Form long chain TAG Reacts to apoprotein (chylomicrons) Absorbed in lymphatic circulation to systemic circulation
Absorption of short and medium chain FA
Readily absorbed
Portal circulation to liver
Absorbed by the lymphatic circulation to systemic circulation
Chylomicrons
Bring up long chain FA and 2 MAG to intestinal cell
Bile salts micelles
Appoprotein, a protein molecule and form lipoprotein molecule called
Chylomicrons
Obstruction of the common bile duct.
Bike doesn’t reach the intestine
Increase amount of digested but unabsorbed fats
Steatorrhea due to bile deficiency
Gives color to stool
Stercobilin
Saan galing ang stercobilin
Sa stercobilinogen na content din ng bile aside from bile salts
Kung ang obstruction ay above the ampula of vater, digeted parin ang fats
2 hepatic duct
Cystic duct
Common bile duct
Increase amount of undigested and unabsorbed fats in the feces
Steatorrhea due to pancreatic juice deficiency
Steatorrhea due to pancreatic juice deficiency
Cause
Chronic pancreatitis
Pancreatic carcinoma
Obstruction on the ampulla of vater
Steatorrhea due to pancreatic juice deficiency
Color of stool
Normal color, no obstruction in the common bile duct
Increased amount of digested but unabsorbed fats in the feces
Normal stool color
Steatorrhea due to abnormal intestinal mucosa
Steatorrhea due to abnormal intestinal mucosa
Causes
Celiac disease due to hypersensitivity reactions
Prolong intake of gluten that destroys the intestinal mucosa
Biosynthesis of non essential fatty acids
Lipogenesis
Fats synthesized in the body
Non essential fatty acids
Fats that cannot synthesized of the body
Essential fatty acids
two kinds of essential fatty acids
Alpha linoleic acid
Linoleic acid
Alpha linoleic acid
Omega 3 fatty acid
Linoleic acid
Omega 6 fatty acid
Difference between saturated and unsaturated fats
Saturated- bad
Unsaturated - good
Example of monounsaturated fatty acids
Palmitoleic acid
Oleic acid
Types of lipogenic pathway
Extramitochondrial lipogenesis
Microsomal lipogenesis
Mitochondrial lipogenesis
Most active and important lipogenic pathway
Extramitochondrial lipogenesis
