Gout Flashcards
Over production or under excretion of uric acid
Hyperuricemia
Gout is deposition of uric acid crystals
Monosodium urate
Stage
Abnormally high serum urate level, wala pa itong gouty arthritis
Asymptomatic hyperuricemia
Stage
Onset of pain, erythema
First attack
Acute gout
90% of acute gour are
Monoarticular
Stage
Intervals between attack
Crystals maybe present
Intercritical gout
Stage
Large enough of sodium urate to be seen on radiograph
Chronic tophaceous gout
Hyper uricemia results primarily from the
Under excretion of uric acid
Inhibits xanthine oxidase, resulting in an accumulation of hypoxanthine and xanthine
Allopurinol
More soluble than uric acid
Hypoxanthine
Xanthine
This enzyme removed amino group from AMP to produced IMP
AMP deaminase
IMP nucleoside form
Inosine
GMP nucleoside form
GUanosine
This enzyme converts IMP and GMP to their nucleoside forms
5 nucleotidase
Inosine purine bases
Hypoxanthine
Guanosine purine bases
Guanine
Enzyme that convert inosine and guanosine to their purine bases
Purine nucleoside phosporylase
Guanine is deaminated to form
Xanthine
Enzyme used to deaminate gusnine to xanthine
Guanase
Hypoxanthine is oxidized by _________ to xanthine
Xanthine oxidase
Xanthine to uric acid is also oxidize by
Xanthine oxidase
Monosodium urate crystals
Gour
Calcium pyrophosphate dihydrate crystals
Pseudo gout
Enzyme which further catalyses uric acid to allantoin
Uricase
Increased activity of this enzyme can lead to over production of pyrin
PRPP synthetase
- reduce the number of white blood cells which travel into the inflamed areas
- helps to break the cycle of inflammation, thus reducing swelling and pain
Colchicine
- removes the extra uric acid from the body
* helps prevent gout attacks only as long as you continue to take it
Probenecid
- used to prevent or treat high uric acid levels in the blood
- is a xanthine oxidase inhibitor that works by causing less uric acid to be produced by the body
- is also used to prevent or treat high uric acid levels that may be caused by cancer medicines or for patients with kidney stones that contain calcium
Allopurinol
is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis such as inflammation, swelling, stiffness, and joint pain.
Celecoxib
