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Biochem Prelim 2nd Sem > Gout > Flashcards

Gout Flashcards

0
Q

Over production or under excretion of uric acid

A

Hyperuricemia

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1
Q

Gout is deposition of uric acid crystals

A

Monosodium urate

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2
Q

Stage

Abnormally high serum urate level, wala pa itong gouty arthritis

A

Asymptomatic hyperuricemia

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3
Q

Stage

Onset of pain, erythema
First attack

A

Acute gout

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4
Q

90% of acute gour are

A

Monoarticular

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5
Q

Stage

Intervals between attack
Crystals maybe present

A

Intercritical gout

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6
Q

Stage

Large enough of sodium urate to be seen on radiograph

A

Chronic tophaceous gout

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7
Q

Hyper uricemia results primarily from the

A

Under excretion of uric acid

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8
Q

Inhibits xanthine oxidase, resulting in an accumulation of hypoxanthine and xanthine

A

Allopurinol

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9
Q

More soluble than uric acid

A

Hypoxanthine

Xanthine

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10
Q

This enzyme removed amino group from AMP to produced IMP

A

AMP deaminase

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11
Q

IMP nucleoside form

A

Inosine

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12
Q

GMP nucleoside form

A

GUanosine

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13
Q

This enzyme converts IMP and GMP to their nucleoside forms

A

5 nucleotidase

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14
Q

Inosine purine bases

A

Hypoxanthine

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15
Q

Guanosine purine bases

A

Guanine

16
Q

Enzyme that convert inosine and guanosine to their purine bases

A

Purine nucleoside phosporylase

17
Q

Guanine is deaminated to form

A

Xanthine

18
Q

Enzyme used to deaminate gusnine to xanthine

A

Guanase

19
Q

Hypoxanthine is oxidized by _________ to xanthine

A

Xanthine oxidase

20
Q

Xanthine to uric acid is also oxidize by

A

Xanthine oxidase

21
Q

Monosodium urate crystals

A

Gour

22
Q

Calcium pyrophosphate dihydrate crystals

A

Pseudo gout

23
Q

Enzyme which further catalyses uric acid to allantoin

A

Uricase

24
Q

Increased activity of this enzyme can lead to over production of pyrin

A

PRPP synthetase

25
Q
  • reduce the number of white blood cells which travel into the inflamed areas
  • helps to break the cycle of inflammation, thus reducing swelling and pain
A

Colchicine

26
Q
  • removes the extra uric acid from the body

* helps prevent gout attacks only as long as you continue to take it

A

Probenecid

27
Q
  • used to prevent or treat high uric acid levels in the blood
  • is a xanthine oxidase inhibitor that works by causing less uric acid to be produced by the body
  • is also used to prevent or treat high uric acid levels that may be caused by cancer medicines or for patients with kidney stones that contain calcium
A

Allopurinol

28
Q

is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis such as inflammation, swelling, stiffness, and joint pain.

A

Celecoxib

Biochem Prelim 2nd Sem (13 decks)

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