Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Biochem Prelim 2nd Sem > Ketogenesis > Flashcards

Ketogenesis Flashcards

0
Q

Three ketone bodies

A

Acetoacetic Acid
Acetone
Beta-HydroxyButyric Acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Biosynthesis of three ketone bodies

A

Ketogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Ketogenesis

Location

A

Mitochondrial fraction of the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Ketogenesis

Substrate

A

Acetyl Coa

From beta oxydation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Ketogenesis

Obligatory intermediate

A

HMG COA or pro Hydroxy Methyl Glutaryl CoA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

May dalawang pathways na kung saan ikaw ay may HMG CoA

A

Ketogenesis

Cholesterol biosynthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Firstketone bodies na masisynthesized ay

A

Aceto acetic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Reaction 1

A

2 Acetyl CoA to

Acetoacetyl CoA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Reaction 1

Enzyme

A

Thiolase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Reaction 2

A

Acetoacetyl CoA + Acetyl CoA to

3 Hydroxy 3 methyl CoA (HMG-CoA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Reaction 2

Enzyme

A

HMG CoA Synthetase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Reaction 3

A

HMG CoA to

Acetoacetic Acid + Acetyl CoA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Reaction 3

Enzyme

A

HMG CoA lyase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Acetoacetic Acid to acetone

Reaction

A

Decarboxylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Acetoacetic Acid to acetone

Reaction process

A

CO2 goes out

CO2 from Carboxyl Group of Acetoacetic Acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Acetoacetic Acid to acetone

Reversible or Irreversible?

A

Irreversible

16
Q

Acetoacetic Acid to Beta Hydroxybutyric Acid

Enzyme

A

Beta hydroxybutyrate DH

17
Q

Acetoacetic Acid to Beta Hydroxybutyric Acid

Reaction

A

Reduction

18
Q

Acetoacetic Acid to Beta Hydroxybutyric Acid

Reducing agent

A

NADH

19
Q

Acetoacetic Acid to Beta Hydroxybutyric Acid

Reaction process

A

Acetoacetic Acid reduced

NAD as electron acceptor to NADH

20
Q

Acetoacetic Acid to Beta Hydroxybutyric Acid

Reversible or irreversible?

A

Reversible

21
Q

Happens when glucose metabolism is impaired

Ketone bodies and fatty acids used instead of glucose

A

Excessive ketogenesis

22
Q

Clinical conditions if with glucose impairment

A

Diabetes mellitus

Starvation

23
Q

Complication if you have diabetes mellitus or starvation

A

Metabolic Acidosis kasi depleted yung bicarbonate

24
Q

Oxidation of ketone bodies

A

Acetoacetic Acid + Succinyl CoA to

Acetoacetyl CoA + Succinic Acid

25
Q

Oxidation of ketone bodies

Enzyme

A

Acetoacetate Succinyl CoA Transferase ( Thiophorase )

Absent in the liver

26
Q

Oxidation of ketone bodies

Enzymatic reaction

A

Transfer CoA from Succinyl to Acetoacetic Acid

27
Q

Acetoacetyl CoA to Acetyl CoA

Enzyme

A

Ketothiolase

28
Q

Acetoacetyl CoA to Acetyl CoA

Type of enzyme

A

Splitting enzyme

29
Q

Acetoacetyl CoA to Acetyl CoA

Reaction process

A

Acetoacetyl CoA split to 2 acetyl CoA

30
Q

Regulation of ketogenesis

A

No allosteric enzyme

No regulatory step

31
Q

Other regulation of ketogenesis

A

Increase rate of lipolysis will increase fatty acids level
Increase rate of beta oxidation will increae production of axetyl CoA
More acetyl CoA shunted to ketogenic pathway, increase production of Ketone bodies

Biochem Prelim 2nd Sem (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions