Synthesis Of Phosphoglycerides Flashcards
De novo biosynthesis of phosphoglycerides
Reaction 1
Phosphatidic Acid to
Cytidine Diacyl Glycerol
De novo biosynthesis of phosphoglycerides
Lecithin Biosynthesis also phosphotidyl Serine and Cephalin
De novo biosynthesis of phosphoglycerides
Reaction 1 enzyme
Cytidine Di Phosphate Di Acyl Glycerol Synthase
De novo biosynthesis of phosphoglycerides
Reaction 1 Co factor
Cytidine TriPhosphate
De novo biosynthesis of phosphoglycerides
Reaction 2
Cytidine Diacyl Glycerol + Serine to
Phophatidyl serine
Pinaka unang phosphoglyceride that is synthesized from the parent compound phosphatidic acid
Phosphatidyl serine
De novo biosynthesis of phosphoglycerides
Reaction 3
Phosphatidyl Serine to Phospatidyl Ethanolamine (cephalin)
De novo biosynthesis of phosphoglycerides
Reaction 3
Enzyme
Decarboxylase
Second specific nitrogen containing phosphoglyceride
Phosphatidyl Ethanolamine or Cephalin
De novo biosynthesis of phosphoglycerides
Reaction 4
Phosphatidyl Ethanolamine or Cephalin + 3 SAM to Phosphatidyl Choline (Lecithin)
De novo biosynthesis of phosphoglycerides
Reaction 4 enzyme
N methyltransferase
De novo biosynthesis of phosphoglycerides
Enzymatic activity
Donate methyl Group to Cephalin to form Lecithin
Same reaction with Lecithin formation
Cardiolipin and Lipositol Biosynthesis
Cardiolipin and Lipositol Biosyntheis different starting compound
CDP diacylglycerol
Acts on primary ester bond on C1
Phospholipase A1
Phospholipase A1 produces
Fatty Acid 1( long chain saturated fatty acid)
Lysophosphoglyceride
Acts on secondary ester bond on C2
Phopholipase A2
Phospholipase A2
Produce
Fatty acid usually arachidonic acid
Cleave on secondary phosphoester bond that connects the phosphorylated side chain 1,2 Diacylglycerol
Phospholipase C
Cleaves the side chain
Phospholipase D
Acts on Lysophosphoglyceride
Acts on primary and secondary phosphoester bond
Phospholipase B
Release by the action of phospholipase A2
Arachidonic acid
Phospholipase A2 release arachidonic acid from cell membrane to
Smooth endoplasmic reticulum
2 enzyme that may act on arachidonic acid
Cyclooxygenase
Lipooxygenase
In cyclooxigenase your going to form
Prostaglandin
Thromboxanes
Prostacyclin
In lipooxygenase form
Leukotrines
What is the meaning of 2 in phospholipase A2
2 double bond
Inhibits phospholipase A2
Cortisol and steroid drugs
PIP2 acted upon by phospholipase C will split i to two second messengers
1,2 diacylglycerol
1,4,5 triphosphate
This second messengers mobilize ______ in the _______
Calcium
Smooth endoplasmic reticulum
2 second messenger may also open the calcium channel in the cell membrane allowing calcium to go inside the cell and by itself ang calcium ay second messenger and it stimulates ___________
Protein kinase C
Cyclic AMP dependent
Protein kinase A
