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Biochem Prelim 2nd Sem > Synthesis Of Phosphoglycerides > Flashcards

Synthesis Of Phosphoglycerides Flashcards

0
Q

De novo biosynthesis of phosphoglycerides

Reaction 1

A

Phosphatidic Acid to

Cytidine Diacyl Glycerol

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1
Q

De novo biosynthesis of phosphoglycerides

A

Lecithin Biosynthesis also phosphotidyl Serine and Cephalin

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2
Q

De novo biosynthesis of phosphoglycerides

Reaction 1 enzyme

A

Cytidine Di Phosphate Di Acyl Glycerol Synthase

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3
Q

De novo biosynthesis of phosphoglycerides

Reaction 1 Co factor

A

Cytidine TriPhosphate

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4
Q

De novo biosynthesis of phosphoglycerides

Reaction 2

A

Cytidine Diacyl Glycerol + Serine to

Phophatidyl serine

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5
Q

Pinaka unang phosphoglyceride that is synthesized from the parent compound phosphatidic acid

A

Phosphatidyl serine

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6
Q

De novo biosynthesis of phosphoglycerides

Reaction 3

A 
Phosphatidyl Serine to
Phospatidyl Ethanolamine (cephalin)
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7
Q

De novo biosynthesis of phosphoglycerides

Reaction 3

Enzyme

A

Decarboxylase

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8
Q

Second specific nitrogen containing phosphoglyceride

A

Phosphatidyl Ethanolamine or Cephalin

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9
Q

De novo biosynthesis of phosphoglycerides

Reaction 4

A 
Phosphatidyl Ethanolamine or Cephalin + 3 SAM to
Phosphatidyl Choline (Lecithin)
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10
Q

De novo biosynthesis of phosphoglycerides

Reaction 4 enzyme

A

N methyltransferase

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11
Q

De novo biosynthesis of phosphoglycerides

Enzymatic activity

A

Donate methyl Group to Cephalin to form Lecithin

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12
Q

Same reaction with Lecithin formation

A

Cardiolipin and Lipositol Biosynthesis

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13
Q

Cardiolipin and Lipositol Biosyntheis different starting compound

A

CDP diacylglycerol

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14
Q

Acts on primary ester bond on C1

A

Phospholipase A1

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15
Q

Phospholipase A1 produces

A

Fatty Acid 1( long chain saturated fatty acid)

Lysophosphoglyceride

16
Q

Acts on secondary ester bond on C2

A

Phopholipase A2

17
Q

Phospholipase A2

Produce

A

Fatty acid usually arachidonic acid

18
Q

Cleave on secondary phosphoester bond that connects the phosphorylated side chain 1,2 Diacylglycerol

A

Phospholipase C

19
Q

Cleaves the side chain

A

Phospholipase D

20
Q

Acts on Lysophosphoglyceride

Acts on primary and secondary phosphoester bond

A

Phospholipase B

21
Q

Release by the action of phospholipase A2

A

Arachidonic acid

22
Q

Phospholipase A2 release arachidonic acid from cell membrane to

A

Smooth endoplasmic reticulum

23
Q

2 enzyme that may act on arachidonic acid

A

Cyclooxygenase

Lipooxygenase

24
Q

In cyclooxigenase your going to form

A

Prostaglandin
Thromboxanes
Prostacyclin

25
Q

In lipooxygenase form

A

Leukotrines

26
Q

What is the meaning of 2 in phospholipase A2

A

2 double bond

27
Q

Inhibits phospholipase A2

A

Cortisol and steroid drugs

28
Q

PIP2 acted upon by phospholipase C will split i to two second messengers

A

1,2 diacylglycerol

1,4,5 triphosphate

29
Q

This second messengers mobilize ______ in the _______

A

Calcium

Smooth endoplasmic reticulum

30
Q

2 second messenger may also open the calcium channel in the cell membrane allowing calcium to go inside the cell and by itself ang calcium ay second messenger and it stimulates ___________

A

Protein kinase C

31
Q

Cyclic AMP dependent

A

Protein kinase A

Biochem Prelim 2nd Sem (13 decks)

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