Treatment principles of T2D Flashcards
1
Q
What are the aims of management?
A
Treat symptoms
- Prevent microvascular complications
aim for HbA1c < 7.0% (53mmol/mol) - Prevent cardiovascular complications
- Screen for complications early while treatable
eye disease (laser)
neuropathy (podiatry)
kidney disease (blood pressure management, ACE inhibitor)
2
Q
What is T2DM and its risk factors?
A
Insulin resistance + beta cell dysfunction = relative insulin deficiency
OR
Impaired insulin secretion is a hallmark of T2DM
Risk factors for T2DM:
*Family history (maternal and paternal metabolic health)
* Genetic factors
* Environmental factor
*Obesity
*Age
*Pregnancy
*Calorie-dense diet
*Sedentary lifestyle
*Epigenetic factors
G high–> Insulin secretion low–> IR high
3
Q
Explain Glucose sensing in alpha cells?
A
4
Q
Why do we need to treat T2DM?
A
because it is not only about BG, it is impo to treat lipids and blood pressure to reduce the risk associate with CVD
