T2DM epidemiology and pathophysiology

Question 1

If one of the parents has T2 the probability is 40%
Twins are higher 76%

Question 2

Increasing age=Increase body weight=Increase risk of dieabtes

Question 3

IR VS Alzheimer’s disease?

Answer 3

Proinflammatory signaling lead to attenuated insulin signaling and decreased cellular responsiveness to insulin—> synaptic dysfunction–> impaired memory

Question 4

Obesity definitely makes you have IR and Diabetic. T/F

Answer 4

F
look at the photo for explanation

Question 5

T2D has increased dramatically in prevalence over the last decade. The greatest prevalence is in —– and ——- countries and this is set to increase

Answer 5

low and middle income

Question 6

T2D is a ——— with over 400 genetic variants identified to date. Individually the genetic effects are small but in combination have a large impact on diabetes risk

Answer 6

heritable trait (genetics)

Question 7

T2D is largely (but not always) a disease characterized by ——— and ———. And therefore, is associated with ———- and ————-.

Answer 7

overweight
IR
Hypertension
Dyslipidaemia

Question 8

Pathophysiology – exceeding fat storage threshold, lipid overspill, ——— and———-

Answer 8

lipotoxicity
vulnerable beta-cells