Insulin Resistance Flashcards
1
Q
What does insulin resistance mean?
A
Organs do not respond to insulin
* Asymptomatic
2
Q
Mechanisms/causes of IR
A
- Impairment of insulin signalling
- Inflammation
- Pathway-selective hepatic IR
3
Q
What are the causes of IR?
A
- Over weight (causes ECM remodelling)
- Excess caloric intake
- Sedentary lifestyle
- Genetics
4
Q
what are the consequences of IR?
A
- Diabetes
- Hypertension
- Alzheimer’s
- chronic kidney disease
- Liver disease
- Gout
- Atherosclerosis
- Hyperlipidaemia
5
Q
What does impaired glucose tolerance mean?
A
Impaired glucose tolerance means that blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis.
6
Q
—– is the gold standard for the measurement of insulin sensitivity
A
The Hyperinsulinemic-euglycemic clamp
