Transmissible encephalopathies Flashcards
1
Q
Transmissible encephalopathies can be diagnosed by detecting infective prions in the brain.
A
T
2
Q
In the case of transmissible encephalopathies lesions can only be seen in the central nervous system
A
F
True?
3
Q
Prion diseases can be diagnosed by detecting the antibodies with ELISA.
A
F
4
Q
There are major differences in the amino acid sequence of the normal and infective prions.
A
F
5
Q
Spongiform encephalopathies of animals occur worldwide except Australia and New Zealand
A
T
6
Q
Prions can become infective prions as a result of a mutation
A
T
7
Q
In the case of transmissible encephalopathies always degenerative lesions can be seen
A
T
8
Q
In the case of transmissible encephalopathies meningoencephalitis is a typical postmortem
lesion
A
F
9
Q
Infective prions are resistant against the usual concentration of disinfectants
A
T
10
Q
Agents of transmissible encephalopathies are most frequently detected with PCR.
A
F
11
Q
Transmissible encephalopathies can be diagnosed by detecting infective prions in the brain.
A
T
12
Q
Weight loss is a clinical sign of Transmissible encephalopathies
A
T
13
Q
Prion diseases can be diagnosed by detecting antibodies with ELISA
A
F
14
Q
ELISA can be used for the detection of infective prions in the brain
A
T
15
Q
The folding of normal and the infective prion is different
A
T
16
Q
Infective prions are resistant against proteases
A
T
17
Q
Infective prions can survive 100 °C.
A
T
18
Q
Prions consist of protein and DNA
A
F
19
Q
Infective prions are resistant against proteases
A
T
20
Q
Infective prions are resistant against the usual concentration of disinfectants
A
T
21
Q
Chronic prion has no nucleic acid inside.
A
T
22
Q
Chronic prion is inactivated by boiling.
A
F
23
Q
Chronic prion form has other form than normal prions.
A
T
24
Q
Prions contain protein and DNA
A
F
25
Mutations can result infective prions
T
26
Infection with infective prions generally happens per os
T
27
In the case of transmissible encephalopathies encephalitis can be seen in the grey material
of the brain
F
28
Transmissible encephalopathies are caused by prions.
T
29
PCR is used to the detection of prions
F
30
Prions always cause viraemia in the infected hosts
F
31
Prions are spreading in the host along the nerves
T
32
Normal prions are essential components of the cell membrane of the hosts
F
33
Infective prions replicate in the cytoplasm of the neurons.
T
| F? misfolding
34
Infective prions are taken per os.
T
35
Encephalitis is typical in the case of transmissible encephalopathies
F
36
Protease breaks down prions
F
37
Transmissible encephalopathies are acute or per-acute diseases
F
38
Antibodies to prions cannot be detected in the case of transmissible encephalopathies.
T
39
Allergy tests are widely used to diagnose transmissible encephalopathies.
F
40
Scrapie has genetic predisposition
T
41
Scrapie prion is shed in discharges of the infected animals
T
42
The EU is free from Scrapie
F
43
Scrapie is a zoonotic disease
F
44
Atypical scrapie strains are not shed by the infected animals
T
45
Scrapie prion is detected with PCR
F
46
Scrapie is a disease of sheep, goats, and cattle
F
47
Scrapie is mainly seen in sheep between 1.5 and 5 years of age
T
48
Itching is a frequent sign of scrapie
T
49
Both typical and atypical scrapie strains can cause itching
F
50
Scrapie has more clinical signs in lambs than adult sheep
F
51
Certain genotypes of sheep are resistant against Scrapie prion
T
52
Scrapie is spreading with per os infection
T
53
Genetic predisposition is needed for scrapie to develop.
T
54
Atypical scrapie strains can cause the same clinical signs as typical scrapie
F
55
Scrapie can be prevented with live vaccines
F
56
Scrapie sensitivity depends on genotype of sheep.
T
57
Scrapie can be transmitted between sheep in a flock.
T
58
Itching is always a clinical sign of scrapie
F
59
In scrapie we can observe lameness
F
60
Scrapie occurs only in Britain and Ireland
F
61
Sheep cannot shed the scrapie prion
F
62
Clinical signs of scrapie are most frequent in animals between 6 and 12 months of age
F
63
Scrapie is seen only in adult sheep
F
64
Scrapie is seen in sheep and goats.
T
65
Goat are resistant to scrapie
F
66
Scrapie is spread within the flock from animal to animal
T
67
Scrapie prion can infect susceptible animals per os
T
68
Itching can be seen in the case of typical scrapie.
T
69
Itching can be seen in the case of atypical scrapie.
F
70
Certain sheep can be resistant to scrapie
T
71
Scrapie can be prevented with inactivated vaccines
F
72
Scrapie prion is shed by the infected animals
T
73
Scrapie can be prevented by using attenuated vaccines
F
74
There is a per os infection in the case of transmissible mink encephalopathy.
T
75
The behaviour of the animals is changed in the case of transmissible mink encephalopathy.
T
76
Transmissible Mink encephalopathy can be transmitted by eating infected meat.
T
77
Transmissible Mink encephalopathy symptoms: being anxious
T
78
Minks are infected with transmissible mink encephalopathy prion per os
T
79
Minks shed the transmissible mink encephalopathy prion in the faeces
F
80
Movement disorders are typical signs of transmissible mink encephalopathy.
T
81
Aggressiveness is a clinical sign of BSE.
T
82
BSE prion causes meningoencephalitis.
F
83
Clinical signs of BSE appear in cattle slowly.
T
84
Movement disorders are typical clinical signs of BSE
T
85
BSE prion is shed in milk in large amount
F
86
BSE prion generally infects cattle in aerosol
F
87
BSE prion travels along the nerves from the gut to the brain
T
88
BSE infects animals per os
T
89
BSE prion generally infects cattle in aerosol
F
90
Enteritis and haemorrhages can be seen postmortem in BSE cattle
F
91
Hyperaesthesia is a clinical sign of BSE
T
92
Calves of cows infected with BSE are frequently infected, they have to be destroyed
F
93
There is no vaccine for the prevention of BSE
T
94
Ataxia is a clinical sign of BSE
T
95
BSE is a zoonotic disease
T
96
BSE is spreading fast in the infected herd
F
97
Clinical signs of BSE can be seen mainly in 1-1.5 years old cattle
F
98
For Bovine spongiform encephalopathy laboratory examination, we use ELISA.
T
99
In Bovine spongiform encephalopathy the meat contains high number of prions
T
100
Creutzfeldt Jakob syndrome is a new type of Bovine spongiform encephalopathy in humans.
T
101
BSE prions are shed in the faeces and it is transmitted to other cattle in the herd
F
102
The incubation time of BSE is 3-5 years.
T
103
Only a few animals show clinical signs of BSE in an infected herd
T
104
Bovine spongiform encephalopathy is widespread in Europe; it is common in most European
countries.
F
105
BSE is not spreading from animal to animal
T
106
In the case of BSE polioencephalitis is the main post mortem lesion
F
107
BSE prion is mainly detected with PCR.
F
108
The agent of bovine spongiform encephalopathy is not shed by the infected animals.
T
109
Antibodies against bovine spongiform encephalopathy are detected with ELISA.
F
110
The agent of bovine spongiform encephalopathy is spreading along the nerves in the
infected animals.
T
111
The agent of bovine spongiform encephalopathy is shed in large number in the milk.
F
112
Changed behaviour is a typical sign of bovine spongiform encephalopathy
T
113
In case of spongiform encephalopathies micro abscesses are in the brain stem
F
114
Spongiform encephalopathies are mainly acute diseases.
F
115
In the case of spongiform encephalopathies there is encephalitis.
F
116
Spongiform encephalopathies can be diagnosed by detecting circulating antibodies
F
117
In the case of spongiform encephalopathies the behaviour of the animal is generally
changed
T
118
In the case of spongiform encephalopathies encephalitis is the main post mortem lesion
F
119
In the case of spongiform encephalopathies high levels of antibodies is produced
F
120
Spongiform encephalopathies are caused by prions.
T
121
Bovine spongiform encephalopathy cannot infect humans.
F
122
Bovine spongiform encephalopathy causes aggression.
T
123
You can diagnose bovine spongiform encephalopathy with ELISA
T
124
Bovine spongiform encephalopathy causes an immune response
F
125
Bovine spongiform encephalopathy is a contact infection.
F
126
Bovine spongiform encephalopathy is spreading fast in the infected herd.
F
127
Clinical signs of BSE can be seen mainly in 1-1.5 years old cattle
F
128
BSE can be seen in calves from the age of 6 months
F
129
Hypersensitivity is a clinical sign of BSE.
T
130
Focal necrosis in the liver is a typical post mortem lesion of BSE
F
131
Antibodies to BSE can be detected with ELISA in infected animals
F
132
2-6 months old calves having BSE are frequently aggressive
F
133
Bovine spongiform encephalopathy is seen only in beef cows.
F
134
Cattle with bovine spongiform encephalopathy have movement difficulties
T
