Transfusion Medicine Flashcards
For all _____, donor and recipient cells are typed for ABO and Rh(D).
transfusions
What reaction causes bronchospasm and large airway response; is usu in IgA deficient individuals; cause unk?
anaphylactic rxn
What is H antigen + fucose + D-galactose?
type B
What is the Rh rule of thumb?
D > > C, E, ē, c > others
What reaction is due to alloantibody production and the slow destruction of the sensitizing RBCs and has very few signs and symptoms?
delayed hemolytic rxn
What is a delayed hemolytic reaction?
alloantibody production and the slow destruction of the sensitizing RBCs; very few signs and symptoms
What is type B blood?
H antigen + fucose + D-galactose
What is an immediate hemolytic transfusion reaction?
transfusion of incompatible blood products; activation of complement and intravascular hemolysis can lead to shock, renal failure, or DIC
What are the 2 most common adverse events in blood transfusions, and what are their treatments?
1) febrile non-hemolytic transfusion rxn (Tylenol) 2) mild allergic rxn (Benadryl)
What are the human RBC alloantigens and what are they made of?
A, B, O, or AB; polysaccharides
What are alloantigens?
differences on the surfaces of RBCs that change their biochemical and immunology but not their functionality
What reaction is due to volume/fluid overload?
Transfusion Related Circulatory Overload (TACO)
What is Transfusion Related Circulatory Overload (TACO)?
volume/fluid overload
What is acute lung injury w/i 6 hours of transfusion?
Transfusion Related Lung Injury (TRALI)
What is an anaphylactic reaction?
bronchospasm and large airway response; usu in IgA deficient individuals; cause unk
What is type A blood?
H antigen + fucose + N-acetylgalactosamine
What is the basic sugar chain on the RBC membrane?
H antigen
What is apheresis?
automated machines take anticoagulated blood from the donor, separate out one or more components by centrifugation and buoyant density, and return the unused components to the donor
What is type O blood?
H antigen + fucose
What reaction is due to transfusion of incompatible blood products and leads to the activation of complement and intravascular hemolysis can lead to shock, renal failure, or DIC?
immediate hemolytic transfusion rxn
What is Transfusion Related Lung Injury (TRALI)?
acute lung injury w/i 6 hours of transfusion
What is the process of using automated machines to take anticoagulated blood from the donor, separate out one or more components by centrifugation and buoyant density, and return the unused components to the donor called?
apheresis
For all transfusions, donor and recipient cells are typed for ___ and ____.
ABO; Rh(D)
What is H antigen + fucose + N-acetylgalactosamine?
type A
What is H antigen + fucose?
type O
