Anemia II Flashcards
What are sideroblastic anemias?
a rare group of congenital or acquired disorders
Name the 7 underproduction anemias.
1) infection
2) inflammation
3) malignant disease
4) renal insufficiency
5) endocrine disorders
6) lead poisoning
7) malnutrition
In _____, TNF decreases iron availability from stores and decreases production of EPO, and INF-β inhibits erythropoiesis.
malignancies and sepsis
In malignancies and sepsis, ____ decreases iron availability from stores and decreases production of EPO, and ____ inhibits erythropoiesis.
TNF; INF-β
In malignancies and sepsis, TNF decreases _____ and ______, and INF-β inhibits _____.
iron availability from stores; decreases production of EPO; erythropoiesis
In ______, IL-1 diminishes iron mobilization and EPO production, and INF-γ inhibits proliferation of erythroid precursors.
chronic infection or inflammation
In chronic infection or inflammation, ___ diminishes iron mobilization and EPO production, and ____ inhibits
proliferation of erythroid precursors.
IL-1; INF-γ
In chronic infection or inflammation, IL-1 diminishes iron _____, and INF-γ inhibits ______.
mobilization and EPO production; proliferation of erythroid precursors
With _____, the lack of EPO causes anemia.
renal insufficiency
With renal insufficiency, the lack of ____ causes anemia.
EPO
In lead intoxication, lead inhibits synthesis of _____ and the enzyme that ______.
protoporphyrin; ligates iron to the porphyrin ring
In _____, lead inhibits synthesis of protoporphyrin and the enzyme that ligates iron to the porphyrin ring.
lead intoxication
What is the treatment for lead intoxication?
chelation therapy
Chelation therapy is the treatment for ____.
lead intoxication
What is the treatment for anemia caused by renal insufficiency?
EPO
