tranexamic acid [TXA] Flashcards
1
Q
Classification
tranexamic acid
A
- hemostatic
- antifibrinolytic agent
2
Q
Pharmacodynamic
tranexamic acid
A
- prevents clot degradation by competing for TPA receptor sites
- inhibits plasminogen conversion to plasmin
3
Q
Pharmacokinetics
TXA
A
IV
onset - immediate
peak - 3hrs
duration - 3hrs
4
Q
INDICATIONs
TXA
A
PCP
- signs of shock // hypoperfusion - in assoc. w/ injury suggestive of occult or ongoing bleeding
☎️ cliniCALL required
- maternal vaginal hemorrhage >20 weeks // postpartum hemorrhage
5
Q
CONTRAINDICATIONs
TXA
A
- HYPERSENSITIVITY
- TIME since injury >3HRs
- GI bleed
- <12 y/o
6
Q
ADVERSE EFFECTs
TXA
A
- may potentiate hypotension, if administered rapidly
7
Q
Dosage - Adult
TXA
A
PCP
2g IV - over 1mins
IV USE ONLY
8
Q
Dosage - Pediatric
TXA
A
PCP
> 12 y/o - 2g IV - over 1min
ACP
<12 y/o - 15mg/kg IV - over 1min
