naloxone [Narcan]

Question 1

Classification

naloxone

Answer 1

Narcotic antagonist

Question 2

INDICATIONs

naloxone

Answer 2

FR
- reversal of resp. depression caused by suspected narcotic intoxication

Question 3

CONTRAINDICATIONs

naloxone

Answer 3

• hypersensitivity
• neonates

Question 4

Dosage - Adult

naloxone

Answer 4

EMR
~~~
1st dose: 0.4 mg IM/IV - q 3mins
2nd dose: 0.4 mg IM/IV
3rd dose: 0.8 mg IM/IV
4th dose : 2 mg IM/IV - (IV preferred)
~~~

palliative pts - titrate 0.1mg IM/IV/min - for reversal of resp depression w/o interfering w/ pain control

☎️ cliniCALL - REQUIRED for further doses

Question 5

Dosage - Pediatric

naloxone

Answer 5

EMR
0.1mg/kg (MAX 2mg) - q 3mins
*higher doses for peds - they are unlikely to experience withdrawal

MAX repeat x 4

Question 6

Pharmacodynamics

naloxone

Answer 6

• competitively antagonizes opioids bound to receptor in the CNS

opiod receptors mu/kappa/gamma - strongest binding to mu receptor

Question 7

Pharmacokintetics

naloxone

Answer 7

**IM/IV **
onset - 1-3mins
peak - 5-15mins
half-life - 1-3hrs
duration - 30-45mins

Question 8

Warnings // Precautions

naloxone

Answer 8

• maybe heat sensitive - may lose potency post 4wks @40C and will require use of higher doses

Question 9

ADVERSE EFFECTs

naloxone

Answer 9

• SUDDEN reversal => combativeness
• S&S of withdrawl
• Hypotension, hypertension
• Nausea, vomiting, sweating,
• Tachycardia

Question 10

Types of Rx narcotics

naloxone

Answer 10

Demerol, Heroin, Codeine, oxymorphone (Numorphan), hypdromorphone (Dilaudid), diphenoxylate (Lomotil), propoxyphene (Darvon) and pentazocine (Talwin)