ondansetron [Zofran]

Question 1

Classification

ondansetron

Answer 1

antiemetic

Question 2

INDICATIONs

ondansetron

Answer 2

PCP
relief of moderate to severe nausea and vomiting

requires PCP/ACP BCEHS-specific education

Question 3

CONTRAINDICATIONs

ondansetron

Answer 3

• HYPERSENSITIVITY
• congenital long QT syndrome
• phenylketonuria (PKU) - may contain aspartame which should be avoided - injection is safe
• 1st trimester pregnancy - ☎️ cliniCALL required

Indigenous higher prevalence of long QT syndrome - use GRAVOL

Question 4

Dosage - Adult

ondansetron

Answer 4

PCP
4mg PO - ODT

single dose, ODT - ondansetron disintegrating tablet

Question 5

Dosage - Pediatric

ondansetron

Answer 5

PCP

6 months - 4 y/o - 2mg PO
4 y/o and up - 4mg PO

single dose

Question 6

Pharmacodynamic

ondansetron

Answer 6

selectively inhibits type 3 serotonergic receptors = nausea supression

Question 7

Pharmacokinetics

ondansetron

Answer 7

PO
onset - 15-30
peak - 30-120mins
duration - 3-4hrs

Question 8

Warnings // Precautions

ondansetron

Answer 8

closely monitor pts for signs of respiratory depression, CNS effects

esp. elderly pts, or w/ hepatic renal failure

Question 9

ADVERSE EFFECTs

ondansetron

Answer 9

• hypotension
• depression // aggitation