ibuprofen Flashcards

1
Q

Classification

ibuprofen

A
  • Analgesic
  • Antipyretic
  • NSAID
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2
Q

Brand Names

ibuprofen

A

Advil
Motrin
Actiprofen

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3
Q

INDICATIONs

ibuprofen

A

FR
- mild to moderate pain

PCP
- mild to moderate pain
- pyrexia

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4
Q

CONTRAINDICATIONs

ibuprofen

A
  • HYPERSENSITIVITY
  • active GI bleed
  • pregnancy (all trimesters)
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5
Q

analgesia

Dosage - ADULT

ibuprofen

A

FR
300-400mg - PO q 4-6hrs
MAX - 1200mg/day

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6
Q

pyrexia

Dosage - ADULT

ibuprofen

A

PCP
300-400mg - PO q 4-6hrs
MAX - 1200mg/day

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7
Q

analgesia

Dosage - PEDATRIC

ibuprofen

A

PCP
10mg/kg PO
repeat x 1 @ 6hrs

MAX dose - 40mg/kg/day

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8
Q

pyrexia

Dosage - PEDATRIC

ibuprofen

A

PCP
* temp < 39°C - 5mg/kg PO q 4-6hrs
* temp ≥ 39°C - 10mg/kg PO q 4-6hrs

MAX dose - 40mg/kg/day

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9
Q

Pharmacodynamics

ibuprofen

A

inhibits prostaglandin synthesis =
- decreased pain
- decreased inflammation
- decreased pyrexia

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10
Q

Pharmacokinetics

ibuprofen

A

PO - analgesic
onset - 30-60mins
peak - 1-2hrs
duration - 4-6hrs

PO - antipyretic
onset - 30min-2.5hrs
peak - 2-4hrs
duration - 6-8hrs

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11
Q

ADVERSE EFFECTs

ibuprofen

A
  • unlikely after single pre-hospital dose, however note NSAIDs use hx
  • GI upset > ulcer > bleeding > perforation
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12
Q

OVERDOSE

ibuprofen

A
  • GI irritation
  • CNS depression

tx - primarily supportive

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13
Q

Warnings // Precautions

ibuprofen

A

consider ALTERNATIVE TX for pt w/
- GI problems
- renal dysfunction
- significant CVS hx

NSAIDS have the potential to cause significant adverse reactions - the RISK increases w/ dose, therapy and underlying risk factors

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14
Q

DRUG INTERACTIONs

ibuprofen

A

NSAID may increase BP, limiting effects of ANTI-HYPERTENSIVES

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