acetylsalicylic acid [Aspirin] Flashcards

1
Q

Classification

ASA

A
  • Antiplatelet
  • Antithrombotic
  • NSAID
  • Antipyretic
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2
Q

INDICATIONs

ASA

A

[EMR]
- Chest pain // signs & symptoms consistent with CARDIAC ISCHEMIA // ?AMI

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3
Q

CONTRAINDICATIONs

ASA

A
  • HYPERSENSITIVITY (to ASA or other NSAIDs)
  • hx bronchospasm/other respiratory distress precipitated by ASA//NSAIDs
  • ACTIVE//recent bleeding of any kind - head injury, stroke, peptic ulcer disease
  • PEDIACTRICs presenting with viral symptoms consistent w/ REYES’s SYNDROME
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4
Q

Dosage - ADULT

ASA

A

162mg - PO

chewed & swallowed

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5
Q

Pharmacodynamic

ASA

A

Inhibits the formation of thromboxane A2 which is a potent platelet aggregate and vasoconstrictor

  • antiplatelet effects are IRREVERSIBLE - lasts for the life of platelets ~7-10 days
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6
Q

Pharmacokinetics

ASA

A

ORAL
onset - 5-30 mins
peak - 1 to 2 hrs
duration - 4-6 hrs

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7
Q

ADVERSE EFFECTS

ASA

A
  • Irritation of the GI tract - COMMON
  • anti-platelet effect&raquo_space; minor bruising/bleeding
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8
Q

OVERDOSE

ASA

A

TOXICITY @ doses
>150mg/kg

  • 150lbs/68kg ~10.2g = ~126 tabs @81mg

symptoms:
- NVD
- diaphoresis
- tinnitus
- hyperventilation

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9
Q

Warnings // Precautions

ASA

A
  • should NOT be used in PEDIATRICs/young adults w/ - chicken pox, influenza, or ILI — RISK of developing REYE’s SYNDROME
  • ETOH use = increase RISK for GI bleeding

REYE’s SYNDROME - encephalopathy, acute liver damage

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10
Q

DRUG INTERACTIONs

ASA

A
  • anti-coagulants = 🤔 cliniCALL for RISK vs BENEFITS of pt experiencing cardiac ischemia
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