Trace Minerals I Flashcards

1
Q

Trace Minerals (Micronutrients) Definition: Trace minerals, also known as____ are nutrients that are needed by the human body in very small amounts (less than ___ ___ of __ percent of total body weight).

A

Trace Minerals (Micronutrients) Definition: Trace minerals, also known as microminerals are nutrients that are needed by the human body in very small amounts (less than one-hundreth of 1 percent of total body weight).

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2
Q

Trace Mineral Content of Foods

Dependent upon:

Composition of ___ and ___

___ of foods.

Many dietary components and other factors within the ___ affect the ____ of minerals.

A

Dependent upon: Composition of soil and water. Processing of foods. Many dietary components and other factors within the body affect the bioavailability of minerals.

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3
Q

Distribution of Trace Minerals

A

Distribution of Trace Minerals

Iron is highest

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4
Q

Dietary Need for the Body

A

* 1 part per million (1 ppm) or less

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5
Q

Most Extensively Studied Trace Minerals

___
___
___
___
___

A

Iron Zinc Selenium Iodine Fluoride

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6
Q

Other Trace Minerals

___ ___ ___ ___

Several others being researched currently…

A

Copper Manganese Chromium Molybdenum Several others being researched currently…

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7
Q

Characteristics of Trace Minerals

Concentrations in the body are ___ ___.

Normal body function necessitates an ___ ___.

Toxicity can occur at intakes__ __ ___ the estimated requirement.

A

Concentrations in the body are highly regulated. Normal body function necessitates an optimal range. Toxicity can occur at intakes not far above the estimated requirement.

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8
Q

Status of Iron

Most people __ __ __ ___ amount of iron because of their dietary choices.

Others consume __ ___ iron (due to intake of iron ____) which may also pose a health hazard.

A

Most people do not get sufficient amount of iron because of their dietary choices. Others consume too much iron (due to intake of iron supplements) which may also pose a health hazard.

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9
Q

Primary Function of Iron

Most of the body’s iron is found in two proteins:

____n (__ __ cells)

___ (____ cells)

A

Most of the body’s iron is found in two proteins: Hemoglobin (red blood cells) Myoglobin (muscle cells)

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10
Q

Role of Hemoglobin

Hemoglobin is the ___ ____ protein of the red blood cell that transports oxygen from the ___ to the body ____.

Hemoglobin accounts for ___ percent of the body’s iron.

A

Hemoglobin is the oxygen-transferring protein of the red blood cell that transports oxygen from the lungs to the body tissues. Hemoglobin accounts for 80 percent of the body’s iron.

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11
Q

Role of Iron in the Body

Transport of ____ to the tissues

____ production

Maintenance of ____

Synthesis of___ ___, ____, __ ___

A

Transport of oxygen to the tissues Energy production Maintenance of immunity Synthesis of amino acids, hormones, and neurotransmitters

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12
Q

Metab of Iron

IRON in food–> ___ cells

Store in____ if not needed, or shed in intestinal cells

If body needs iron Package iron in ____

Transferrin carries iron in blood

Some lost

Iron to ___

__ __ incorporates iron into ___. Store excess in ___ and ___

Iron containing Hb carries __. Some losses if bleeding occurs

___ and ___ break down blood cells and ____ iron in transferrin. Store excess in ferritin and hemoderin

A

Metabolism of Iron

IRON in food–> intestinal cells

Store in ferritin if not needed, or shed in intestinal cells

If body needs iron Package iron in transferrein

Transferrin carries iron in blood

Some lost

Iron to Myoglobin

Bone marrow incorporates iron into Hb. Store excess in ferritin and hemoderin

Iron containing Hb carries O2. Some losses if bleeding occurs

Liver and spleen break down blood cells and package iron in transferrin. Store excess in ferritin and hemoderin

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13
Q

Heme and Nonheme Iron in Foods

Only foods derived from ____ flesh provide heme but they also contain ____e iron

All the iron in foods derived from plants is ____e iron

Heme accts for about ___% of the avg daily iron intake, but ___% of the iron is absorbed

A

Heme and Nonheme Iron in Foods

Only foods derived from animal flesh provide heme but they also contain nonheme iron

All the iron in foods derived from plants is nonheme iron

Heme accts for about 10% of the avg daily iron intake, but 35% of iron is absorbed

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14
Q

Factors That Affect Iron Absorption Increase

___ ___

___ iron in food

High body demand for ___ ___ ___ (blood ___,___ altitude, physical ___, ___)

Low body ____ of iron

___ ___ ___(MPF)

Vitamin ___

A

Factors That Affect Iron Absorption

Gastric acid

Heme iron in food

High body demand for red blood cells (blood loss, high altitude, physical training, pregnancy

Low body stores of iron

Meat protein factor (MPF)

Vitamin C

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15
Q

Factors That Affect Iron Absorption Decrease

___ ___ (in dietary ___)

___ ___in ___ ___

____ in __, as well as in ___, ___ ___, andother foods

____ body stores of iron

Excess of other ____(__ ___ ___)*

____ gastric acid output

Some ____

* Especially when taken as supplements

A

Factors That Affect Iron Absorption Decrease

Phytic acid (in dietary fiber)

Oxalic acid in leafy vegetables

Polyphenols in tea, as well as in coffee, red wine, and

other foods

Full body stores of iron

Excess of other minerals (Zn, Mn, Ca)*

Reduced gastric acid output

Some antacids

* Especially when taken as supplements

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16
Q

Transport and Storage of Iron

A

Transport and Storage of Iron

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17
Q

Recommended Dietary Allowances for Adults

Males: ____

Females (19-50yrs): ____/day

Females (51+):___/day

A

Males: 8mg/day Females (19-50yrs): 18mg/day Females (51+): 8mg/day

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18
Q

Significant Food Sources of Iron

___

__
___
___

___
___ ___

A

Red meat Fish Poultry Eggs Legumes Dry fruits

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19
Q

Meat Fish Poultry (MFP) Factor MFP factor: A factor associated with the ____ of meat, fish, and poultry that ____ absorption of iron.

A

MFP factor: A factor associated with the digestion of meat, fish, and poultry that enhances absorption of iron.

20
Q

Iron Absorption: Other Important Facts

Iron absorption varies with an individual’s___ , ___ ___ and iron ___/status.

Can vary from ____ percent, with an average of 18 percent.

Iron absorption is enhanced with higher needs such as pregnancy and other life stages characterized by __ ___ (infancy and childhood).

A

Iron absorption varies with an individual’s health, life stage and iron needs/status. Can vary from 2-35 percent, with an average of 18 percent. Iron absorption is enhanced with higher needs such as pregnancy and other life stages characterized by rapid growth (infancy and childhood).

21
Q

Iron Deficiency: Anemia Definition:

Severe depletion of ___ __ that results in ___ emoglobin and ___, ___, red blood cells (_____, _____).

A

Definition: Severe depletion of iron stores that results in low hemoglobin and small, pale, red blood cells (microcytic, hypochromic).

22
Q

Nutrient-Deficient Anemias

___

___ - vitamin _

___

Other Vitamins, e.g., _

A

Iron Cobalamin - vitamin B12 Protein Other Vitamins, e.g., B6

23
Q

Other Conditions That Can Lead to Anemia

____

___ Abnormalities

____ disease states

____

____

____ disease

___ toxicity

A

Hemorrhage Genetic Abnormalities Chronic disease states Cancer Hypothyroidism Cardiovascular disease Drug toxicity

24
Q

Populations Vulnerable to Iron Deficiency

___
____

___ during____ years

____ women

A

Infants Adolescents Women during childbearing years Pregnant women

25
Q

Symptoms of Iron-Deficiency Anemia

___
___
____ ____ to ____

__ ___ ____

___ ___ ___ (in ____)

A

Fatigue Anorexia Reduced capacity to work Poor immune response Impaired cognitive function (in children)

26
Q

Treatment of Iron-Deficiency Anemia

Treatment will depend upon the underlying ___ and ____.

Includes ___y modifications, ____, and appropriate ____.

Severe iron-deficiency anemia may require a ___ ___n, ___ ___, or ___ __ ___. Treatment may need to be done in a ___

A

Treatment will depend upon the underlying cause and severity. Includes dietary modifications, supplements, and appropriate medications. Severe iron-deficiency anemia may require a blood transfusion, iron injections, or intravenous iron therapy. Treatment may need to be done in a hospital.

27
Q

Toxicity/Iron Overload * An estimated __% of the population in the United States is in positive iron balance, with _% having iron overload.

* Two types -________s and _____

A

* An estimated 10% of the population in the United States is in positive iron balance, with 1% having iron overload. * Two types - Hemochromatosis and Hemosiderosis.

28
Q

Iron and Heart Disease Recent research has linked iron overload (high blood iron) with an increased risk of ___ ____

(Possible mechanism: free iron ___ ___, and oxidized LDL is more damaging to the ___ ___).

A

Recent research has linked iron overload (high blood iron) with an increased risk of heart disease. (Possible mechanism: free iron oxidizes LDL, and oxidized LDL is more damaging to the cardiovascular system).

29
Q

ZINC

Most of the zinc in the body is concentrated in __ ___ ___ ____ tissues.

Amount of zinc in the adult human body ranges from ___-___ grams.

A

Most of the zinc in the body is concentrated in bone, liver, kidney and muscle tissues. Amount of zinc in the adult human body ranges from 1.5-2.5 grams.

30
Q

Primary Functions of Zinc

A

Cofactor for more than 100 enzymes Cellular growth (DNA synthesis) Bone formation Cell-mediated immunity Part of insulin Thyroid function Behavior and learning performance

31
Q

Recommended Dietary Allowances for Adults

Males (19-50 years): __mg/day

Females (19-50 years): __mg/day

A

Males (19-50 years): 15mg/day Females (19-50 years): 12mg/day

32
Q

Deficiency of Zinc Human zinc deficiency was reported in the 1960s in ____ and adolescent ____ in Egypt, Iran, and Turkey.

___ ___ ___ are associated with higher zinc needs.

A

Human zinc deficiency was reported in the 1960s in children and adolescent boys in Egypt, Iran, and Turkey. Rapid growth phases are associated with higher zinc needs.

33
Q

Populations Vulnerable to Zinc Deficiency VPATES

A

Alcoholics Trauma patients Lacto-vegetarians Pregnant women Elderly Post-surgical patients

34
Q

Symptoms of Zinc Deficiency

___Growth retardation
___Skeletal abnormalities
___Collagen Syn
___H poor wound heeling
___M sexual maturity
____Taste diminished hypoguiseria

A

Growth retardation Skeletal abnormalities Defective collagen synthesis Poor wound healing Delayed sexual maturation (children) Hypogeusia (diminished taste)

35
Q

Significant Food Sources of Zinc

_____
____
_____

A

Protein-containing foods: meat, fish, poultry Whole grains Vegetables e.g. green peas

36
Q

Metabolism of Zinc

A

Metabolism of Zinc

37
Q

Absorption of Zinc and Copper

Zinc and copper in foods

Zinc induces the syn of ____ which ___ both ions and __ ___

High ion need: Ions are transferred in the ____ and bind to transport proteins

Low ion need: Zn and Cu are ___d into the ____ with sloughed mucosal cell

A

Absorption of Zinc and Copper

Zinc in copper foods

Zinc induces the syn of metallothionein which binds both ions and limits absorption.

High ion need: Ions are transferred in the blood and bind to transport proteins

Low ion need: Zn and Cu are shed into the intestine with sloughed mucosal cell

38
Q

Metabolism of Zinc Various Steps

Zinc in food absorbed by ___ ____.

Attached to ___ and ____ and ____ in blood.

Excess stored in the ____ as ____.

____ uses zinc to make___ ____.

Some losses in ___ ___ ___ and ___

A

Zinc in food absorbed by intestinal cells. Attached to albumin and transferrin and circulated in blood. Excess stored in the liver as metallothionein. Pancreas uses zinc to make digestive enzymes. Some losses in urine, skin, blood, and semen.

39
Q

Selenium: Primary Functions

____
_____ for ____ ____

A

Antioxidant Co-factor for Glutathione Peroxidase

40
Q

The Glutathione Peroxidase System

–>

——–glutathioine peroxidase—>

A

The Glutathione Peroxidase System

Peroxidases–> Cell damage by free radicals

Peroxidases——–glutathioine peroxidase—> Alcohols and H20

41
Q

Recommended Dietary Allowances for Adults

Adults:_____/day

Upper Level: ____/day

A

Adults: 55µg/day Upper Level: 100µg/day

42
Q

Selenium Deficiency (Observed in China)

___ ___
___ ___ ____

A

Keshan Disease Kashin-Beck’s Disease

43
Q

Keshan Disease

_____

____ ___ ____

_____ of ___ ___

A

Cardiomyopathy Congestive Heart Failure Necrosis of heart tissue

44
Q

Kashin-Beck’s Disease

A disorder of the ____ and___ of the ___ ____ ____ ___ ____s in ____ and ____.

This occurs due to necrosis (____) of the ___ ___of___ AnD ___ ___

A

A disorder of the bones and joints of the hands, fingers, elbows, knees and ankles in children and adolescents. This occurs due to necrosis (death) of the growth plates of bones and joint cartilage.

45
Q

Selenium and Cancer

___ ___ ____correlates with a high incidence of certain kinds of cancer.

Selenium supplements may not be ____ in prevention.

A

Selenium-poor soil correlates with a high incidence of certain kinds of cancer. Selenium supplements may not be effective in prevention.