Toxicology

Question 1

Cattle with perilobular hemorrhage

Answer 1

aflatoxins?

Question 2

Phenotiazine toxicity in horses

Answer 2

Hyperamonemia liver damage and photosenzitation

Question 3

Diagnosis of lead poisoning in chronic cases

Answer 3

Preferred: Free erythrocyte porphyrins and erythrocyte concentrations of ALA
Bone concentrations
Give EDTA and measure after urine and blood concentrations

Question 4

Molybdenum toxicity, effects

Answer 4

Decrease Cu

Question 5

Toxic dose cantharidin

Answer 5

4-6g or 100 beetles

< 1 mg/Kg

Question 6

Oleander toxicosis in alpacas, effect?

Answer 6

Block Na/K ATPase, increase Ca intracell

Bradycardia

Question 7

Mechanism of action of lead toxicosis

Answer 7

• Acute –> Lead substitutes Ca–> Inhibit O2 utilization for prod ATP–> neuro
▫ –> GI signs (bloat, diarrhea…)
• Chronic–>*Interference with synthesis of heme

Question 8

Alpaca cria with Hypercalcemia and hyperphosphatemia

Answer 8

VIT D toxicosis

Question 9

Cyclops in sheep

Answer 9

Veratrum californicum

Question 10

Zn deficiency, effects?

Answer 10

Hair depigmentation, alopecia around eyes, diarrhea, anemia

Question 11

Cause of Cu deficiency in herds

Answer 11

high Fe pasture

Question 12

Nigropallidal malacia in a horse

Answer 12

Russian knapweed

Question 13

Cantharadin toxicity protein loss where?

Answer 13

?

Question 14

Herd of cows horses, sheep that is ataxic, tremors, etc. grazing in ryegrass. Cause?

Answer 14

Acremonium lolli

Question 15

Toxicity lamb death?

Answer 15

?

Question 16

Diagnosis of lead poisoning in acute cases

Answer 16

Blood or tissue concentrations. Collect in tube with heparin