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LAIM > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Clenbuterol

A

β2-adrenergic agonist

Bronchial, vascular, uterine smooth muscle relaxation

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2
Q

N-Butylscopolammonium bromide

A

Anticholinergic
Inhibit muscarinic rcpts on smooth muscle
→ bronchodilation, ↓ GI contraction, ↑HR

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3
Q

Cimetidine blocks cytochrome P450, interactions?

A

interact with propanolol, benzodiazepines, metronidazol, theophylline (no DMSO)

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4
Q

About ketoconazole and itraconazole when using acid suppression therapy

A

Decrease absorption

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5
Q

Sulfonylureas

A

Oral glycemic agent

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6
Q

Diazepam mechanism of action

A

Induction of GABA

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7
Q

Trimethoprim mechanism of action

A

Inhibition of dehydrofolate reductase

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8
Q

Fluconazole oral bioavailability

A

Drug with high oral bioavailability in horses

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9
Q

Foal in anesthesia is normal but you need to increase the peripheral vascular resistance, which drug would be the best to use:

A

phenylephrine

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10
Q

What drug should not be used in large animals with hepatic insufficiency:

A

Halothane

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11
Q

Multiresistant drug pathogen, mechanism?

A

Genetic mutation

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12
Q

Methicillin resistant S. aureus, ATB to use?

A

Chloramphenicol

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13
Q

Mechanisms of bacterial resistance

A

Mutation, adaptation

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14
Q

Potency of dexamethasone vrs prednisolone

A

7x as potent

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15
Q

Antibiotic with effect in DNA gyrase

A

Enrofloxacin (fluoroquinolones)

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16
Q

Anti-platelet mechanism of aspirin

A

COX-1

17
Q

Side effects of TMS

A

Anemia

18
Q

Mechanism of action of aminoglycosides

A

30S ribosomal subunit. Cell death

19
Q

Mechanism of action of metronidazole

A

DNA breakage, inhibition of DNA repair

20
Q

Antibiotic with high concentration in lung tissue

A

Tetracyclines

21
Q

Mechanism of action of doxycycline

A

30S ribosomal subunit

22
Q

Mechanism of action of aspirin

A

?

23
Q

Mechanism of gabapentin

A

GABAergic, blocks Ca channels

Decrease synthesis of glutamate

24
Q

Topoisomerase inhibitor, mitose

A

Fluoroquinolone

25
Q

Mechanism of action of neostigmine

A

Inhibit cholinesterase. Prolong Ach activity by retarding breaking down at synaptic junction
For LARGE intestine

26
Q

Mechanism of action of metoclopramide

A

5-HT4 agonist + dopamine (DA2) antagonist

↑Gastric emptying, ↑gastroduodenal coordination

27
Q

Mechanism of action of metformin

A

Increase glucose uptake in tissues by promoting AMP-dep PK

LAIM (20 decks)

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