Respiratory Flashcards
Effects of alveolar hypoxia
vasoconstriction
Hypoventilation is due to which acid base disturbance?
Metabolic alkalosis
Negative prognostic indicator in R. equi pneumonia
Intra-abdominal abscess Osteomyelitis
Virulence factor of Manheimia hemolytica?
Leukotoxin
Cattle with cough, harsh dorso-caudal lung sounds, subcutaneous edema
BRSV
Diagnostic method for verminous pneumonia
Baermann
Most common cell in RAO BAL
Neutrophils
Sheep with cough, weight loss, hard udder
Ovine progressive pneumonia (OPP)
Cow in feedlot with fever, cough, red nose
BHV-1
Treatment of horse with strangles
Horses with early clinical signs • ATB on early stage, before abscessation (3-5 days) • May prevent local abscess and shedding Horses with lymph node abscessation • Supportive care • Soft food • NSAIDs, hot compress, drainage, lavage • ATB recommended if horse is depressed, anorectic, dyspneic • Penicillin → drug of choice • Cephalosporins, macrolides • ATBs may prevent development of lasting immunity
Diagnosis for Cryptococcus neoformans
Latex agglutination
Most important immune cell for R. equi
T lymphocytes?
Cow with lesion in lung caudodorsally
Bovine respiratory syncytial virus
Pathogenensis R. equi and decreased immune (macrophage) response
Lipoarabinominam on bacterium surface and Macrophage phagocytosis of R. equi
Diagnosis of Chronic carrier state for S. equi
Guttural pouch fluid/swab PCR
Fungi that most commonly causes pneumonia in horses
Coccidiomicosis
Horse with a nasal granuloma (mass), histopathology revealed large amounts of eosinophils around the lesions
Condidiobolus coronatus
What test to run in a horse that had been exposed to S. equi 3 weeks before
SeM ELISA? Nasal PCR?
What is the best immune response against R. equi:
IFN-y
What is the best for monitoring and early diagnosis of R. equi pneumonia in endemic farms:
CBC, monitoring for fever, cough
Adult cow with respiratory signs, mild, fever, tachypnea:
BHV-1, BRSV?
Acute interstitial pneumonia in cattle, associated with?
Hyperplasia of pneumocytes type 2
With respect to BRSV and vaccination of calves before 1 month old
vaccination of calves before 1 month old is not effective.
Lesions of Haemophilus in cattle
Pleuritis, myocarditis, fibrinopurulent pneumonia
Elimination of EIV Australia
canary pox 14 days
BRSV and vaccination of neonatal calves
Non protective
Zoonotic in dog and horse?
Blastomycosis?
Lung mechanism of IAD
?
Drug of choice of Pneumocystis carinii
TMS
Vaccination of EIV
Canary q14d
Vaccine with highest efficacy to decrease BRDC?
Killed: BVDV MLV: BHV-1, BRSV, PI3
EIPH, what is associated with?
Histology changes
In strangles, what is a positive nasal PCR
Actively shedding
Pulse oxymeter at 90
60 mmHg
Pneumocytes II
Lush pastures
Immune response in R. equi pneumonia
IFN-g –> macrophages
How to determine strangles titer?
SeM protein
Requisite for M. haemolytica vaccine
Leukotoxin
What is the function of the surface glycoproteins in BHV-1 infection?
Surface glycoproteins gC, gD, gB interact with heparan sulfate proteoglycans for cell attachment and entry
In BHV-1, how are the lungs in necropsy?
Lesions in respiratory, ocular, and reproductive mucosa, but do NOT extend to the lungs. “Boom!”
Effects on vaccine for BRSV
Th2 response After intranasal vaccine –> IgA
Which is the most common virus isolated from lungs of calves euthanized for pneumonia
Bovine parainflueza 3
Effect of bovine PI3 in RBCs
Hemagglutinates and hemadsorbs
Serotypes causing pneumonia in Manheimmia hemolytica
A1 –> Cattle A2 –> Sheep and goats
Main characteristic of M. hemolytica lung lesions
CV, fibrinous pleuritis **Necrotizing fibrinous pleuropneumonia**
Virulence factor for M. hemolytica
Leukotoxin –> CD18 receptor Also: PS capsule, IROM P
ATBs to be used in prophylaxis for M. hemolytica
Tilmicosin, florfenicol
Serogroup causing pneumonia in P. multocida
A3
“Calf pneumonia” is usually referred to which infectious agent?
P. multocida
What is a main feature of the clinical presentation of P. multocida pneumonia
Chronic or ongoing pneumonia
Main features in the pathogenesis of H. somni
Binds to Fc in antibody –> preventing opsonization Vasculitis and vascular thrombi Induce IgE
Most time of infection for H. somni
First 2 months or 2 weeks of the feeding period
Why is Mycoplasma bovis resistant to b-lactams?
Bacteria lacks cell wall
Syndrome caused by Mycoplasma bovis
Chronic pneumonia and polyarthritis
Resistant to ATB
Virulence factor of M. bovis
Variable surface proteins (VSPs)
Lack of cell wall –> resistant to b-lactams
Sources of infection for M. bovis
Contact Aerosol Infected milk
Lung lesions for M. bovis
Caseonecrotic lesions Foci of coagulation necrosis
Test for carriers of Mycoplasma mycoides-large colony type
PCR of auricular swabs
Important source of infection of M. mycoides LCT
Does that recover from mastitis become chronic carriers
M. mycoides-large colony type
*hot swollen joints*
Prevention of m. mycoides LCT
Feed heat treated colostrum, or cow colostrum at birth, then pasteurized milk or replacer from 1 month to weaning
“Fog fever”
Acute Bovine Pulmonary Edema and Emphysema
Cause of ABPEE
L-tryptophane from lush pastures –> 3-Methylindole
3 important features of ABPEE
- Absence of coughing 2. No signs of sepsis 3. No adventitious lung sounds
Target cells is ABPEE
Type I pneumocytes and Clara cells
Moldy Sweet Potato
4 - Ipomeanol toxicity –> interstitial pneumonia
Diagnosis of extrinsic allergic alveolitis “bovine farmer’s lung”
Antibody to S. rectivirgula
Treatment for D. viviparus
Ivermectin -> 3, 8, 13 weeks Doramectin -> 0, 8 weeks If treatment during PPP -> larvae never shed in feces
Most common lung worm in small ruminants
Muellerius capillaris
Muellerius capillaris: where is the adult parasite located?
Goat: subpleural tissue Sheep: nodules
Best treatment for M. capillaris
1 week on/1 week off/1 week on with fenbendazole *Resistant to levamisole