Immunology Flashcards
Cells affected in horses with congenital immune deficiency
B lymphocytes?
What kind of immunodeficiency causes SCID in foals?
Combined (B and T cells)
Deficiency in IFN-g
What is the cause of the Common Variable Immunodeficiency in foals?
Hypo or agammaglobulinemia (low IgG and IgM)
B cell lymphopenia (impairment B-cell in bone marrow)
What causes of neurological signs in a foal with Neonatal Isoerythrolysis?
Kernicterus (hyperbilirrubninemia)
Lifespan of RBCs after a transfusion
2-4 days
In NI, which blood group causes more serious disease
Antigen Aa
3 conditions for production of a NI foal
1st → Mare has to be negative for the Ag
2nd → Mare has to be sensitized and produce Abs
3rd → Foal must have inherited the Ags from the sire
What is a mare ‘at risk” to produce NI foals?
Negative for Aa and Qa
Breed this mares with negative stallions
Which test can be used to test colostrum before a foal at risk for NI can nurse?
Jaundice agglutination test
Which type of tests are more reliable to detect alloantibodies in mare’s colostrum or serum
Lytic tests
Trait for Chediak-Higashi syndrome
Autosomal recessive
Clinical signs of Chediak-Higashi syndrome
Dilution pigment (Albinism), eye abnormalities, risk infections, bleeding tendency
Mutation for Bovine Leukocyte adhesion deficiency
Autosomal recessive (holstein) Mutation gene coding for CD18 (B2 integrins)
What are the effects of Bovine Leukocyte adhesion deficiency
Large number neutrophils intravascular but very few extravascular
Trait for severe combined immunodeficiency
Autosomal recessive (arabians)
