Toxic Shock Syndrome

Question 1

What is it?

Answer 1

Caused by toxins produced by bacteria staph aureus or strep pyogenes
Produce systemic inflammatory response leading to widespread tissue damage and organ dysfunction

Question 2

What are clinical features?

Answer 2

Rapid onset
Fever
Hypotension
Sunburn like rash
Headache
Diarrhoea and Vomiting
Multi organ dysfunction e.g. hypoxia, AKI

Question 3

What is found on investigation?

Answer 3

Diffuse erythroderma
Mucosal hyperemia
Signs of shock

Question 4

How is it diagnosed?

Answer 4

Clinical presentation with supporting lab
- raised WCC and CRP
- positive blood cultures

Question 5

What is the management?

Answer 5

Critical Care
IV fluids
IV abx
Vasopressor support
Manage complications

High morbidity and mortality if not recognised and treated promptly