ToRCHes infections Flashcards
infection that passes from mother to infant during pregnancy or delivery
many cause congenital malformations: growth retardation, intellectual disability, hepatosplenomegaly, miscarriage, stillbirth
ToRCHes
ToRCHeS
Toxoplasma gondii Other: parvovirus B19 Rubella CMV HIV, HSV-2 e Syphilis
maternal infections that can cause neonatal meningitis
GBS
E.coli
Listeria monocytogenes
infections are more severe if:
primary infection during pregnancy
transmission: cat feces or undercooked meat
toxoplasmosis: toxoplasma gondii (protozoa)
congenital infection has this triad:
chorioretinitis
hydrocephalus
intracranial calcifications
toxoplasmosis: toxoplasma gondii (protozoa)
congenital infection:
infection of RBC precursors → severe fetal anemia, CV failure → hydrops fetalis (fluid accumulating in different parts of body: ascites, pleural effusions)
parvovirus B19
childhood infection:
“slapped cheek rash” →lacy reticular rash on chest and shoulders
erythema infectiosum (fifth disease): parvovirus B19
adult infection:
arthritis
parvovirus B19
children: mild fever + rash
rubella
congenital infection has this triad: cataracts PDA sensorineural deafness blueberry muffin" rash: areas of extramedullary hematopoiesis
rubella
adult: mononucleosis-like syndrome
CMV (most common)
congenital infection:
jaundice
hepatosplenomegaly
sensorineural hearing loss (witha mom who has mononucelosis-like syndrome)
CMV
concern of transmission during L&D (not pregnancy)
HIV and HSV
prevention of HIV transmission
HAART during pregnancy if high viral load: intrapartum zidovudine during delivery C-section after delivery: zidovudine prophylaxis to infant AVOID breastfeeding
vesicular skin rash conjunctivitis pneumonia CNS: meningoencephalitis disseminated disease: sepsis
HSV
prevention of HSV transmission
suppression with acyclovir starting at 36 wks
if active genital infection at time of labor or prodromal sx: C-section
congenital infection:
early sx (onset during first 2 years of life)
hepatomegaly, elevated LFTs
rash followed by desquamation of hands and feet
snuffles: blood-tinged nasal secretions
skeletal abnormalities
late sx due to scarring/inflammation: (onset after first 2 years of life)
frontal bossing
interstitial keratitis (corneal scarring → blindness)
saddle nose deformity
hutchinson teeth (nothing of upper incisors)
perforation of hard palate
saber shins (anterior bowing of tibia)
syphliis
treatment of syphlis in pregnant patient with pen allergy?
#1 desensitize patient #2 penicllin G (best treatment)
