arachidonic acid derivative effects + drugs

Question 1

drug inhibits lipoxygenase → blocks luekotriene formation

Answer 1

zileuton

Question 2

drug inhibits leukotriene receptor of LTC4, LTD4, LTE4

Answer 2

zafrilukast

montelukast (for young children)

Question 3

drug inhibits phospholipase A2

Answer 3

corticosteroids

Question 4

drugs inhibit COX-1/COX-2

Answer 4

NSAIDs
acetaminophen (inactivate peripheral COX, no anti-PLT or anti-inflammatory effects)
aspirin (irreversible)
celocoxib (COX-2 inhibitor)

Question 5

AA product causes ↑ bronchial tone

Answer 5

LTC4, D4, E4

TXA2

Question 6

AA product causes ↓ bronchial tone

Answer 6

PGI2 (prostacyclin)

PGE2, F2α (prostaglandin)

Question 7

AA product causes ↑ PLT aggregation

Answer 7

TXA2

Question 8

AA product causes ↓ PLT aggregation

Answer 8

PGI2 (prostacyclin)

Question 9

AA product causes ↑ uterine tone

Answer 9

PGE2, F2α (prostaglandin)

Question 10

AA product causes ↓ uterine tone

Answer 10

PGI2 (prostacyclin)

Question 11

AA product causes ↑ vascular tone

Answer 11

TXA2

Question 12

AA product causes ↓ vascular tone

Answer 12

PGI2 (prostacyclin)

PGE2, F2α (prostaglandin)