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PHRM 864 therapeutics > Topoisomerase/Microtubule Inhibitor > Flashcards

Topoisomerase/Microtubule Inhibitor Flashcards

1
Q

Irenotecan class

A

topo I inhibitor

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2
Q

irenotecan cell cycle target

A

s phase

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3
Q

irenotecan resistance

A

PgP overexpression
GST overexpression
topo down regulation/mutation

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4
Q

what should be tested before starting irenotecan

A

UGT1A1 for low expression

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5
Q

doxorubicin class

A

topo II inhibitor
intercolator
free radical damage

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6
Q

doxorubicin cell cycle target

A

non specific

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7
Q

doxorubicin dose limiting side effects

A

cardiotoxicity & local tissue damage

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8
Q

what drug should be given with doxorubicin

A

dexrazoxane

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9
Q

doxorubicin resistance

A

PgP & MRP overexpression
GST over expression
Topo II downregulation/mutation
increase in DNA repair

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10
Q

Etoposide class

A

Topo II inhibitor

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11
Q

etoposide cell cycle target

A

G2 cell block

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12
Q

etoposide resistance

A

PgP & MRP overexpression
Topo II downregulation/mutation
increase in DNA repair

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13
Q

Bleomycin class

A

intercolator
free radical damage

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14
Q

bleomycin cell cycle target

A

G2 and M phase

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15
Q

bleomycin dose limiting side effect

A

pulmonary toxicity

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16
Q

Vincristine class

A

microtubule destabilizer

17
Q

vincristine cell cycle target

A

G2 and M phase

18
Q

vincristine dose limiting side effect

A

neurotoxicity

19
Q

vincristine resistance

A

PgP pumping drug out

20
Q

Paclitaxel class

A

microtubule stabilizer

21
Q

Paclitaxel cell cycle target

A

M phase

22
Q

Paclitaxel dose limiting side effects

A

myelosuppression/neurotoxicity

23
Q

Paclitaxel resistance

A

PgP pumping drug out

24
Q

erubulin class

A

microtubule destabilizer

25
Q

erubulin cell cycle target

A

G2 and M phase

26
Q

erubulin dose limiting side effects

A

lower neurotoxicity

27
Q

ixabepilone class

A

microtubule stabilizer

28
Q

ixabepilone cell cycle target

A

m phase

29
Q

ixabepilone resistance

A

not cross resistance and poor pgp substrate

PHRM 864 therapeutics (26 decks)

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