Cancer Drug study sheet Flashcards
5-FU class
pyrimidine analog
Cytarabine class
cytosine analog
6-MP class
purine analog
methotrexate class
antifolate
enzalutamide class
androgen receptor antagonist
abiraterone class
a-hydrolyase inhibitor
tamoxifen class
SERM
fulvestrant class
ER antagonist
letrozole class
non-steroidal aromatase inhibitor
exemestane class
steroidal aromatase inhibitor
leuprolide class
GnRH analogs
imatinib class
Type II kinase inhibitor of Abl-TK
ponatinib class
Bcr-Abl inhibitor
Midostaurin class
1st gen broad kinase inhibitor
Quizartinib class
FLT3 kinsase inhibitor
Crenolanib class
2nd gen specific kinase inhibitor of FLT3
sirolimus class
rapalog
dabrafenib class
BRAF v600 inhibitor
Trametinib class
inhibits MEK1 and MEK2 for BRAF
Acalabrutinib class
BTK inhibitor
Gefitinib class
type 1 TKI
Lapatinib class
TKI blocking HER2 and EGFR
Afatinib class
covalent inhibitor of ErbB
Tucatinib class
TKI blocking HER2
Osimertinib class
covalent kinase inhibitor
chlorambucil class
alkylator
cyclophosphamide class
alkylator
mitomycin c class
alkylator
cisplatin class
platinum
irenotecan class
topo i inhibitor
doxorubicin class
topo ii inhibitor
intercalator
free radical damage
etoposide class
topo ii inhibitor (religation)
bleomycin class
intercolates and free radical damage
vincristine class
microtubule destabilizer
erubulin class
microtubule destabilizer
paclitaxel class
microtubule stabilizer
ixabepilone class
microtubule stabilizer
pembrolizumab class
human mab to PD-1 and block PD-L1
atezolizumab class
human mab to PD-L1 and block PD-1
ipilimumab class
human mab to CTLA-4
trastuzmab pertuzimab class
humanized mab
cetuximab class
chimeric mab
bevacizumab class
humanized mab
rituximab class
CD20 antibody
daratumumab class
CD38 antibody
olaparib class
PARP inhibitor
palbociclib class
CDK4/6 inhibitor
bortemzomib class
proteasome inhibitor
venetoclax class
BCL-2 inhibitor
pomalidomide class
degrades IKZF-TFs
TDM1 class
ADC
trastuzumab-deruxtecan class
ACD
blinatumomab class
Bite to CD3
mosunetuzumab class
bite to CD3 and CD20
teclistamab class
bite to CD3 on T cells
taquetamab class
bite to CD3 on t cells
when are antimetabolites/antifolates cell cycle specific
S phase during DNA replication
what is a dose limiting side effect of antimetabolites/antifolates
myelosuppression
how does leucovorate work with 5-FU
will increase efficacy of drug by increasing FH4 and therefore increase amount of complex to bind to thymidine synthase
what is the rescue drug for 5-FU
Thymidine
what is the resistant mechanism to 5-FU
down regulation of activating enzymes
upreg of thymidine synthase
deficiency of enzyme that breaks down 5-FU
how does tetrahydrouridine affect cytarabine
its a CDA inhibitor and will increase efficacy and decrease resistance of drug
resistance for cytarabine
down reg of activators
upreg of detoxers
down reg of transport into cells
what drug increases toxicity with 6-mp
allopurinol will increase toxicity
what should you test before 6-mp starts
loss of TMPT
what is the rescue drug for methotrexate
leucovorin
resistance to MTX
amplification of DHFR gene or mutation
decreased polyglutamation will pump out more of drug
resistance mechanism to enzalutamide
mutation in Androgen receptor
what is enzalutamide used for
prostate cancer
what is a negative effect of abiraterone
increased cholesterol
what is abiraterone used for
prostate cancer
tamoxifen genetic testing
ER+/PR+
who can use tamoxifen
pre and post menopausal breast cancer
fulvestrant genetics
ER+ breast cancer
who can use fulvestrant
post menopause
who can use letrozole
post menopause
who can use exemestane
ER+ breast cancer in post menopause
what is leuprolide used for
pre menopause BC and prostate cancer
what drugs require a gene test for Abl
imatinib and ponatinib
what drug targets the FTL3 gene
midostaurin
crenolanib
what drug targets ALK wild type
alectinib
what drug targets the ITD mutation
quizartinib
what KI drug targets BRAF mutations
dabrafenib
trametinib
what drug targets EGFR mutation
gefitinib
afatinib
osimertinib
what drug has resistance to T790M
gefitinib
what drug do you use with T790M mutation
osimertinib
what drug targets EGFR + HER2
Lapatinib
what KI is selective for HER2 mutation
tucatinib
what dose limitations do alkylators have
myelosuppression
what is a dose limiter for cisplatin
nephrotoxicity
what phase does cisplatin target
G1 more than S
how does glutathione affect cisplatin
decreases activity
what drug has to be given with cyclophosphamide
mesna (bladder toxicity)
what cell cycle does irenotecan target
s phase
what cell cycle does doxorubicin target
non cell cyclewhat
what cell cycle does etoposide target
G2 cell block
what does cell cycle does bleomycin target
G2 and M phase
what cell cycle does vincristine target
G2 and m phase
what cell cycle does paclitaxel target
M phase
what cell cycle does erubulin target
G2 and M phase
what cell cycle does ixabepilone target
M phase
dose limiting doxorubicin
cardiotoxicity and tissue damage
dose limiting bleomycin
pulmonary toxicity
dose limiting vincristine
neurotoxicity
dose limiting paclitaxel
myelosuppression
dose limiting erubuline
lower neurotoxicity
what is a resistant mechanism for all topo/microtubule drugs
PGP overexpression
what gene to test irenotecan
UGT1A1