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PHRM 864 therapeutics > Cancer Drug study sheet > Flashcards

Cancer Drug study sheet Flashcards

1
Q

5-FU class

A

pyrimidine analog

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2
Q

Cytarabine class

A

cytosine analog

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3
Q

6-MP class

A

purine analog

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4
Q

methotrexate class

A

antifolate

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5
Q

enzalutamide class

A

androgen receptor antagonist

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6
Q

abiraterone class

A

a-hydrolyase inhibitor

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7
Q

tamoxifen class

A

SERM

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8
Q

fulvestrant class

A

ER antagonist

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9
Q

letrozole class

A

non-steroidal aromatase inhibitor

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10
Q

exemestane class

A

steroidal aromatase inhibitor

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11
Q

leuprolide class

A

GnRH analogs

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12
Q
A
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13
Q

imatinib class

A

Type II kinase inhibitor of Abl-TK

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14
Q

ponatinib class

A

Bcr-Abl inhibitor

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15
Q

Midostaurin class

A

1st gen broad kinase inhibitor

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16
Q

Quizartinib class

A

FLT3 kinsase inhibitor

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17
Q

Crenolanib class

A

2nd gen specific kinase inhibitor of FLT3

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18
Q

sirolimus class

A

rapalog

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19
Q

dabrafenib class

A

BRAF v600 inhibitor

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20
Q

Trametinib class

A

inhibits MEK1 and MEK2 for BRAF

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21
Q

Acalabrutinib class

A

BTK inhibitor

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22
Q

Gefitinib class

A

type 1 TKI

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23
Q

Lapatinib class

A

TKI blocking HER2 and EGFR

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24
Q

Afatinib class

A

covalent inhibitor of ErbB

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25
Q

Tucatinib class

A

TKI blocking HER2

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26
Q

Osimertinib class

A

covalent kinase inhibitor

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27
Q

chlorambucil class

A

alkylator

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28
Q

cyclophosphamide class

A

alkylator

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29
Q

mitomycin c class

A

alkylator

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30
Q

cisplatin class

A

platinum

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31
Q

irenotecan class

A

topo i inhibitor

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32
Q

doxorubicin class

A

topo ii inhibitor
intercalator
free radical damage

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33
Q

etoposide class

A

topo ii inhibitor (religation)

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34
Q

bleomycin class

A

intercolates and free radical damage

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35
Q

vincristine class

A

microtubule destabilizer

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36
Q

erubulin class

A

microtubule destabilizer

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36
Q

paclitaxel class

A

microtubule stabilizer

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36
Q

ixabepilone class

A

microtubule stabilizer

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37
Q

pembrolizumab class

A

human mab to PD-1 and block PD-L1

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38
Q

atezolizumab class

A

human mab to PD-L1 and block PD-1

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39
Q

ipilimumab class

A

human mab to CTLA-4

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40
Q

trastuzmab pertuzimab class

A

humanized mab

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41
Q

cetuximab class

A

chimeric mab

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42
Q

bevacizumab class

A

humanized mab

43
Q

rituximab class

A

CD20 antibody

44
Q

daratumumab class

A

CD38 antibody

45
Q

olaparib class

A

PARP inhibitor

46
Q

palbociclib class

A

CDK4/6 inhibitor

47
Q

bortemzomib class

A

proteasome inhibitor

48
Q

venetoclax class

A

BCL-2 inhibitor

49
Q

pomalidomide class

A

degrades IKZF-TFs

50
Q

TDM1 class

A

ADC

51
Q

trastuzumab-deruxtecan class

A

ACD

52
Q

blinatumomab class

A

Bite to CD3

53
Q

mosunetuzumab class

A

bite to CD3 and CD20

54
Q

teclistamab class

A

bite to CD3 on T cells

55
Q

taquetamab class

A

bite to CD3 on t cells

56
Q

when are antimetabolites/antifolates cell cycle specific

A

S phase during DNA replication

57
Q

what is a dose limiting side effect of antimetabolites/antifolates

A

myelosuppression

58
Q

how does leucovorate work with 5-FU

A

will increase efficacy of drug by increasing FH4 and therefore increase amount of complex to bind to thymidine synthase

59
Q

what is the rescue drug for 5-FU

A

Thymidine

60
Q

what is the resistant mechanism to 5-FU

A

down regulation of activating enzymes
upreg of thymidine synthase
deficiency of enzyme that breaks down 5-FU

61
Q

how does tetrahydrouridine affect cytarabine

A

its a CDA inhibitor and will increase efficacy and decrease resistance of drug

62
Q

resistance for cytarabine

A

down reg of activators
upreg of detoxers
down reg of transport into cells

63
Q

what drug increases toxicity with 6-mp

A

allopurinol will increase toxicity

64
Q

what should you test before 6-mp starts

A

loss of TMPT

65
Q

what is the rescue drug for methotrexate

A

leucovorin

66
Q

resistance to MTX

A

amplification of DHFR gene or mutation
decreased polyglutamation will pump out more of drug

67
Q

resistance mechanism to enzalutamide

A

mutation in Androgen receptor

68
Q

what is enzalutamide used for

A

prostate cancer

69
Q

what is a negative effect of abiraterone

A

increased cholesterol

70
Q

what is abiraterone used for

A

prostate cancer

71
Q

tamoxifen genetic testing

A

ER+/PR+

72
Q

who can use tamoxifen

A

pre and post menopausal breast cancer

73
Q

fulvestrant genetics

A

ER+ breast cancer

74
Q

who can use fulvestrant

A

post menopause

75
Q

who can use letrozole

A

post menopause

76
Q

who can use exemestane

A

ER+ breast cancer in post menopause

77
Q

what is leuprolide used for

A

pre menopause BC and prostate cancer

78
Q

what drugs require a gene test for Abl

A

imatinib and ponatinib

79
Q

what drug targets the FTL3 gene

A

midostaurin
crenolanib

80
Q

what drug targets ALK wild type

A

alectinib

81
Q

what drug targets the ITD mutation

A

quizartinib

82
Q

what KI drug targets BRAF mutations

A

dabrafenib
trametinib

83
Q

what drug targets EGFR mutation

A

gefitinib
afatinib
osimertinib

84
Q

what drug has resistance to T790M

A

gefitinib

85
Q

what drug do you use with T790M mutation

A

osimertinib

86
Q

what drug targets EGFR + HER2

A

Lapatinib

87
Q

what KI is selective for HER2 mutation

A

tucatinib

88
Q

what dose limitations do alkylators have

A

myelosuppression

89
Q

what is a dose limiter for cisplatin

A

nephrotoxicity

90
Q

what phase does cisplatin target

A

G1 more than S

91
Q

how does glutathione affect cisplatin

A

decreases activity

92
Q

what drug has to be given with cyclophosphamide

A

mesna (bladder toxicity)

93
Q

what cell cycle does irenotecan target

A

s phase

94
Q

what cell cycle does doxorubicin target

A

non cell cyclewhat

95
Q

what cell cycle does etoposide target

A

G2 cell block

96
Q

what does cell cycle does bleomycin target

A

G2 and M phase

97
Q

what cell cycle does vincristine target

A

G2 and m phase

98
Q

what cell cycle does paclitaxel target

A

M phase

99
Q

what cell cycle does erubulin target

A

G2 and M phase

100
Q

what cell cycle does ixabepilone target

A

M phase

101
Q

dose limiting doxorubicin

A

cardiotoxicity and tissue damage

102
Q

dose limiting bleomycin

A

pulmonary toxicity

103
Q

dose limiting vincristine

A

neurotoxicity

104
Q

dose limiting paclitaxel

A

myelosuppression

105
Q

dose limiting erubuline

A

lower neurotoxicity

106
Q

what is a resistant mechanism for all topo/microtubule drugs

A

PGP overexpression

107
Q

what gene to test irenotecan

A

UGT1A1

PHRM 864 therapeutics (10 decks)

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