Ovarian cancer therapeutics Flashcards
describe the incessant ovulation theory
increased risk of ovarian cancer with increased # of ovulations in one’s lifetime
what are risk factors for ovarian cancer
BRCA 1/2, HNPCC
when do most ovarian cancer patient present
advanced stages
what is the first line approach for ovarian cancer
Surgery + adjuvant chemo therapy
with relapse ovarian cancer what is the treatment
palliative
what is the surgery for ovarian cancer and what are the two groups it is divided in
debulking surgery
optimally debulked < 1cm of disease
sub-optimally debulked > 1cm remaining
can you do a second surgery for ovarian cancer
no, this is not standard of care
what is the chemo regimen for ovarian cancer
paclitaxel + Carboplatin (AUC of 5-7.5)
how is carboplatin dosed in ovarian cancer
AUC x (GFR +25)
what reaction is common with chemo in ovarian cancer
hypersensitivity reactions
what is type 1 hypersensitivity
initial contact with agent (anaphylaxis)
what is type IV hypersensitivity
delayed reaction due to repeated exposure to agent
what are the standard pre-medications for paclitaxel
Dexamethasone
Diphenhydramine
Famotidine
what hypersensitivity is most common with carboplatin
type IV
what drugs can be added and continued after chemo
Bevacizumab
PARP inhibitors
