Kinase Inhibitors Final Exam

Question 1

Imantinib drug class

Answer 1

type II inhibitor of Abl-TK

Question 2

what should be tested prior to starting imantinib?

Answer 2

Abl gene

Question 3

ponatinib drug class

Answer 3

Bcr-Abl inhibitor

Question 4

what should be tested before starting ponatinib

Answer 4

Abl gene

Question 5

Midostaurin drug class

Answer 5

1st gen broad kinase inhibitor

Question 6

Midostaurin target

Answer 6

FTL3 mutation

Question 7

Quizartinib class

Answer 7

Type II kinase inhibitor

Question 8

Quizartinib target

Answer 8

ITD mutations

Question 9

Crenolanib class

Answer 9

2nd gen specific kinase inhibitor

Question 10

Crenolanib target

Answer 10

FTL3 mutations

Question 11

sirolimus drug class

Answer 11

rapamycin analog

Question 12

sirolimus target

Answer 12

inhibit mTOR

Question 13

Alectinib class

Answer 13

ALK inhibitor

Question 14

Dabrafenib class

Answer 14

BRAF v600 inhibitor

Question 15

trametinib class

Answer 15

MEK1 and MEK2 inhibitor

Question 16

Acalabrutinib class

Answer 16

BTK inhibitor

Question 17

Gefitinib classs

Answer 17

type 1 EGFR inhibitor

Question 18

Gefitinib resistance mechanism?

Answer 18

t790M

Question 19

Lapatinib class

Answer 19

TKI for Her2 + EGFR

Question 20

Afatinib class

Answer 20

type I EGFR inhibitor/ErbB

Question 21

tucatinib class

Answer 21

TKI blocking HER2

Question 22

Osimertinib class

Answer 22

kinase inhibitor EGFR

Question 23

what KIs have rash associated as a side effect

Answer 23

gefitinib and afatinib

Question 24

when to use osimertinib

Answer 24

with a T790M mutation

Question 25

who should not be on trametinib

Answer 25

patients who previously received BRAF therpy