Antimetabolites/Antifolates Final Exam

Question 1

5-FU class

Answer 1

pyrimidine analog

Question 2

5-FU cell cycle target

Answer 2

s phase
DNA replication

Question 3

what drug will increase efficacy of 5-FU

Answer 3

leucovorate

Question 4

what is the rescue drug for 5-FU

Answer 4

thymidine

Question 5

resistance mechanism for 5-FU

Answer 5

downregulation of activating enzymes
upregulation of thymidine synthase
deficiency of enzyme that breaks down 5-FU

Question 6

cytarabine class

Answer 6

cytosine analog

Question 7

cytarabine cell cycle target

Answer 7

s phase
DNA replication

Question 8

cytarabine drug interactions

Answer 8

tetrahydrouridine will increase efficacy and decrease resistance

Question 9

resistance for cytarabine

Answer 9

downreg of activators
upreg of detoxers
down reg of transport into cell

Question 10

6-MP class

Answer 10

purine analog

Question 11

6-MP cell cycle target

Answer 11

s phase
DNA replication

Question 12

6-MP drug interactions

Answer 12

allopurinol will increase toxicity
loss of TMPT will increase toxicity

Question 13

6-MP resistance

Answer 13

no tmpt = more toxic

Question 14

what should be tested prior to starting 6-MP

Answer 14

TPMT

Question 15

methotrexate class

Answer 15

antifolate

Question 16

methotrexate cell cycle target

Answer 16

s phase
dna replication

Question 17

methotrexate rescue drug

Answer 17

leucovorin

Question 18

resitance to methotrexate

Answer 18

amplification of DHFR gene
mutation to DHFR resistant form
drug pumped out more

Question 19

what is the dose limiting side effect for all antimetabolites/folates

Answer 19

myelosuppression