Melanoma Therapeutics Flashcards
what are the two hereditary syndromes that are indicative of melanoma
FAMMS
HDNS
what is ABCDE
asymmetric
borders
color
diameter
evolution
stage IV melanomas should be tested for what?
BRAF V600E mutations
when should surgery be offered?
early disease with increased margins the thicker the tumor
how to treat IB/IIA lymph node negative melanoma
clinical trial or observation
how to treat IIB/IIC lymph node negative melanoma
clinical trial
observation
pembrolizumab
how to treat stage III melanoma
Nivolumab
pembrolizumab
dabrafenib/trametinib
+/- radiation
observation
what happens to patients when first starting immunotherapy
look worse, but can get better
how to treat completely resected stage IIIB/IIIC melanoma
adjuvant nivolumab/pembrolizumab or
adjuvant dabrafenib/trametinib if BRAF mutation
what is first line therapy in metastatic melanoma
Anti PD1 monotherapy
Nivolumab
Pembrolizumab
what is second line treatment in metastatic melanoma
pembrolizumab w/ low dose ipilimumab (more SEs)
is chemo useful in melanoma
no. rarely cures or helps in melanoma
