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Developmental Biology > Tooth Development 3: Root Development > Flashcards

Tooth Development 3: Root Development Flashcards

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AP® Biology flashcards Biology 101 flashcards
1
Q

what is the final goal of a functioning tooth

A

fulfil role in oral cav
on outside need enamel
inside need vital parts

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2
Q

what are the major parts of tooth needed for funtionin

A 
enamel 
coronal dentine
root dentine 
cementum
pulp
alveolar bone
PDL
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3
Q

what is the crown aspect

A

enamel and dentine

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4
Q

what is the formation of enamel

A

epi to ameloblast to enamel

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5
Q

what is the formation of dentine

A

dental papilla to odontoblasts to dentine

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6
Q

what does formation of the crown require

A

reciprocal induction

epi signal required for initiation of dentine formation

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7
Q

what are the constituents of the root

A

dentine

cementum

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8
Q

what is the formation of the dentine

A

dental papilla to odontoblasts to dentine

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9
Q

what is the formation of cementum

A

dental follicle to cementoblasts to cementum

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10
Q

what are the dental papilla and dental follicle tissues

A

ectomensenchymal so need an epi initiating signal

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11
Q

what is root development driven by

A

henrtwigs epi root sheath

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12
Q

what is henrtwigs epi root sheath use in development of

A

apical dev of cervical loop region
OEE and IEE
define root morhophlogy

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13
Q

how does the HERS define root morphology

A

inductive influence on root morphogenesis and cementogenesis indirectly

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14
Q

what else done HERS do

A 
proliferates - cell div apically 
disintegrates cervically (cell rest)
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15
Q

what is dental follicle origin

A

ectomesenchyme

- mesodermal origin

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16
Q

where is dental follicle

A

between enamel organ and bone

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17
Q

what does dental follicle give rise to

A

cementoblasts
fibroblasts
osteoblasts

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18
Q

what do cementoblasts do

A

form cementum

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19
Q

what do fibroblasts do

A

form PDL collagen fibres

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20
Q

what do osteoblasts do

A

forms alveolar bone - make socket in situ around tooth

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21
Q

doe the dental follicle affect gingival tissues

A

no

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22
Q

what are the 3 layers of dental follicle

A

inner investing - vascular become cemntoblasts
loose CT
outer - lines alveolus with bone

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23
Q

what does eruption of tooth need

A

anchoring
growth of root
more dentine and pre-dentine

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24
Q

what happens as tooth erupts

A

enamel matrix proteins binds to dentine and predentine form hyaline layer of hopewell smith

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25
Q

what GF’s does HERS produce

A

BMP4
EGF
TGF(beta)

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26
Q

what si the transcription factor used by HERS

A

Shh

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27
Q

what s the first stage of HERS action

A

induces odontoblast formation

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28
Q

what si the second stage of HERS action

A

pre dentine then dentine form

HERS basal lamina breaks down

29
Q

when the hERS basal lamina breaks down what does this mean

A

epi cannot attach to dentine

30
Q

what si the third stage of HERS action

A

HERS cells secrete enamel matrix proteins (amelogenins) on predestine surface

31
Q

what does the action of amelogenins mean

A

lay down enamel
mineralised
ameloblast attachment is prevented
hyaline layer formed

32
Q

what is the fourth stage of HERS action

A

enamel matrix proteins mineralise to forth hyaline layer of hopewell smith

33
Q

what is the fifth stage of HERS action

A

HERS disiitnegrates
no basal lamina
lack of ability to bind to hyaline layer

34
Q

what is the sixth stage of HERS action

A

induction of follicle cells

- migrate to root surface and form cementoblasts

35
Q

how is the induction of the follicle cells induced

A

GF’s

36
Q

how can the follicle cells attach

A

mesenchymal origin so don’t need basal lamia to watch as interact with matrix

37
Q

what is the seventh stage of HERS action

A

cementoblasts secret cementum matrix and retreat outwards

38
Q

what is cementum

A 
collagen 1
fibronectin
osteocalcin 
osteopontin
DMP1
Cementum matrix protein 
GF's - BMP2/4/7
39
Q

what sit he eight stage of HERS action

A

cementum matrix mineralises

entrapping PDL fibres

40
Q

what does the PDL entrapment mean for he tooth

A

extra strength

41
Q

what are the PDL fibres

A

collagen

42
Q

what sit he ninth stage of HERS action

A

remnants of HERS from cell rests to malassez in PDL - cystic potential

43
Q

what si the cel fate HERS

A

with age num of cell rests decrease (props apoptosis) also EMT

44
Q

what is thought of th cell rests action

A

go through mesenchymal transisiton

45
Q

in the developing area of the roots what is found

A 
cementum 
hyaline layer
dentine 
predentine 
HERS cells
odontoblasts 
cemntoblasts 
rafts epi cels
46
Q

what are developing cells proliferating into

A

dental papilla

47
Q

where is the hyaline layer

A

between dentine and predentine

48
Q

what is the hyaline layer

A

highlymineralised

10uM thick sp size

49
Q

what si the hyaline layer origin

A

matrix from
epi cells - enamel matrix protein
ectomesenchymal cells

50
Q

what is the ole of the hyaline layer

A

induced cementoblasts formation

cements cementum to tooth

51
Q

what is cementogenesis

A

form cementum

calcified CT cover roots

52
Q

what are the two types of cementogenesis

A

acellular primary

cellular secondary

53
Q

what are cementoblalss derived form

A

dental follicle

54
Q

what do cememntoblasts do

A

depo matrix - precementum

collagen

55
Q

what is acellular slow to do

A

increase thickness

56
Q

what collagen type is most abundant in PDL

A

collagen 1

57
Q

what si the alveolus

A

bone that forms around the tooth germ

58
Q

what doe the alveolus come form

A

outerlayerof mesenchyme

59
Q

when the tooth erupts what happens to the alveolus

A

resorption of bone to allow tooth thorugh

60
Q

what do HERS cells cause osteogenically

A

differetiaion form bone cells

61
Q

what are gubernacular canals

A

area between apex of deciduous and permanent tooth germ

CT though the alveolus bone

62
Q

where is PDL

A

between cementum and alveolar bone

63
Q

what does he PDL do

A

support the tooth

64
Q

what doe thePDL comtain

A

sp CT that attach unrealised tissue covering root dentine to alv bone

65
Q

what does PDL prod

A

masses of collagen fibres and hyalouronan

GF’s - TGF(beta) EGF

66
Q

whataresome collagen fibres found around the tooth

A 
horizontal 
alveolar crest 
circumferential 
dentine-gingival 
trans-septal
inter-radicular
oblique 
apical
67
Q

what is theintermedivte plexus

A

controversy

between bone and dentine collagen fibres

68
Q

what are the number of roots controlled by

A

controlled by DP

sub division and prolif make extra roots under FGF’s

Developmental Biology (12 decks)

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