Cell- Cell Interactions Flashcards
what si CT
structural
hold cells body together
collagen nd elastin
what is mesenchyme
body - mesodermal origin head neck - ectomesoderm origin loose unspecialised gelatinous
what is developed from mesenchyme
CT bone cartilage Circulatory system Lymphatic system
what are 4 fundamental aspects of developmental biology
proliferation/growth size
pattern formation
morphogenesis shape
differentiation
what is pattern formation
is the process by which cells develop embryo acquire identities that lead to a well ordered spatial pattern of cell activities
what is sequentially
iminig of events
what is reciprocal
one in control of other
what is dynamic
happen quickly
what are the two types of tissue intercation
instructive
permissive
what is instructive tissue intercation
ability of one tissue to determine sp patterns of morphogenesis and diff that will develop in an assc tissue
what is permissive tissue interactions
ability to provide certain conditions that is necessary for its committed partner tissue to progress to full expression of its pre determined phenotype
what is a homotypic interaction
same time, place and species
what is a heterotypic interaction
unrelated usually same time and sp
what is a heterochronic intercation
same type and sp but diff time
what is a heterosp interaction
similar areas but diff species
what is organogenesis
secondary interactions
patterning right place
what si organ rudiment
morphogenesis
proliferation
what is organ sp structures
differentiation
what are some experiments for cell cell interactions
early work tissue recombination organ culture filters organ culture trowel dish bead implantation in situ hybridisation
what is a tooth organ culture
100 yrs ago
hanging drop cultures
culture medium, chick plasma, embryo extract
what is the nucelopore filter method
matrix biology other in vivo assays
what si the trowel cultures method
lead to all sorts of possibilities in recomb
- homo/heterotypic, heterochronic, heterosp and mutants
what happens in tooth development
simple form of organ culture
embryological classes
what is mouse initiiatio embryological class
E9/10
what si the bud, cap and bell embryological class
bud - E12
cap- E14
bell - E16
what si the differentiation of cell types during tooth development like
cells more specialised amorphous blob dynamic reciprocal sequential
what are cytokines and what happens during development
small mols move small dist
receptors and signalling
RNA sun of other cytokines and ECM mols
what is BMP4
cytokine
E11 in dental lamina
what is the heparin bead experiment =
induce MSX1 an MSX 2 and other transcription factors
what is the extracellular matrix imp in
morphogenesis differentiation adhesion migration proliferation polarisation
what does the ECM of the developing tooth contain
collagen IV
fibronectin
tenascin
syndecan
what are the stages of oral development
interaction between oral ectoderm and mesoderm
