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Developmental Biology > Odontogenesis: Tooth Dev 1 > Flashcards

Odontogenesis: Tooth Dev 1 Flashcards

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1
Q

what is histogenesis

A

differentiation of undid cells to make new tissues

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2
Q

what is mineralised dental tissues

A

enamel, dentine and cementum and UNMINERALISED dental tissues - dental pulp and periodontium

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3
Q

what is dental lamina

A

contributes to development of teeth

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4
Q

what is vestibular lamina

A

contributes to the vestibule of mouth, form sulcus

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5
Q

what is the invitation stage

A

first stage of tooth dev

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6
Q

what si the bud stage

A

second stage
spherical to ovoid
epi condenses poorly

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7
Q

what si the cap stage

A

3rd stage of tooth dev

tooth germ grows into cap shape

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8
Q

what is the bell stage

A

4th stage

differentiation occurs to furthest extent resemble bell

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9
Q

what is the crown stage

A

fully dev tooth

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10
Q

what is the external enamel epi

A

outer layer of cuboidal cells that limit the enamel origin

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11
Q

what si the stellate reticulum

A

of epi origin
behave like mesenchymal cells
syn collagen 1,2,3

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12
Q

what is stratum intermedium

A

2 or 3 layers of cells sitting above IEE

express alkaline phosphatase

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13
Q

what is inner enamel epi

A

columnar shaped cells rich in RNA

connected by desmosomes

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14
Q

what is ectomesehcyme

A

neural crest cells

mesodermal somites

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15
Q

what does the primary epi band give rise to

A

dental lamina

vestibular lamina

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16
Q

what does the vestibular lamina do

A

grows then breaks down

froms vestibule between teeth and lips/cheeks

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17
Q

tooth dev is 3 phases

A

initiation
morphogenesis
histogenesis

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18
Q

what does the epi give rise to

A

ectoderm
enamel
hyaline layer of root

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19
Q

what does the mesenchyme give rise to

A

ectomesenchyme

  • dentine
  • pulp
  • cementum
  • periodontium (PDL and bone)
20
Q

when is the first sign of tooth development

A

6 weeks i.u

21
Q

what happens in initiation of tooth dev

A

localised epi thickening in incisor and molar regions

22
Q

which tissues initiates tooth dev

A

epi
ecotmesenchyme or nerve
tissue remobinations

23
Q

why are a couple of important genes involved in tooth dev

A

MSX 1/2

24
Q

what does the dental lamina do in germ

A

continues to lengthen

changes shape

25
Q

what happen in tooth germ to ectomesenchyme

A

condensation

26
Q

what are the components of tooth germ

A

enamel origin
dental papilla
dental follicle

27
Q

what is sen at the bud stage

A

spherical/ovoid epi condensation
cell prolif
no morhpo/histognesis

28
Q

what is seen at the cap stage

A

cap shaped enamel organ
poorly histodiff
little morphogen

29
Q

what is seen at the early bell stage

A

morphs and hist diff

30
Q

what is the enamel origin in the early bells stage

A

inner enamel epi
startup intermedium
stellate reticulum
outer enamel epi

31
Q

what does the ecotmesenhcyme do int he early bell stage

A

dental papilla - forms odontoblast and pulp

dental follicle - forms cemetnuem, PDL and bone

32
Q

what are the enamel organ component

A

inner enamel epi
stratum intermedium stellate reticulum
outer enamel epi

33
Q

what does the inner enamel epi contain

A

basal lamina = ADJ
columnar cells at cusp tips
ameloblasts = enamel

34
Q

what does stratum interediam contain

A

flattened cells

35
Q

what is the role oft he stratum intermedian

A

syn and transport to and from IEE

36
Q

what is the stellate reticulum composed of

A

star shaped cells

fluid filled extrcell space

37
Q

what s the osmotic gradient due to in the stellate reticulum

A

extracellular GAG’s

38
Q

what is the role of the stellate reticulum

A

maintain shape and protection

39
Q

what is the role of the outer enamel epi

A

maintenance of shape and exchange

40
Q

what does the outer enamel epi made of

A

cuboidal cells

41
Q

what are the transitory structures

A

enamel knot
enamel niche
enamel septum

42
Q

what si the enamel knot important for

A

signalling centre

BMP, Shh, MSX1

43
Q

what si the enamel nice

A

2d - hole

3d - depression

44
Q

what does the enamel septum do

A

aid change in shape from cap to bell

45
Q

what is the extracellular matrix important in

A 
morhpgensis
differentiation
adhesion
prolif
migration
polarisation
46
Q

what does the extracellular matrix do

A

express type 1,2,3 collagens
laminin
proteoglycans

47
Q

what does the extracellular matrix cause changes in

A

fibronectin
tenascin
typ 1,2,3 collaneg
syndecan

Developmental Biology (12 decks)

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