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Developmental Biology > Tooth Development 2: Late Bell & Crown stages > Flashcards

Tooth Development 2: Late Bell & Crown stages Flashcards

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AP® Biology flashcards Biology 101 flashcards
1
Q

when is crown formation

A

14th week

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2
Q

when does crown formation take place

A

late bell stage

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3
Q

what is present at late bell stage

A

tooth germ

no hard tissue matrix laid at this point

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4
Q

when do cervical loop cells divide

A

bella nd crown stages

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5
Q

what does the division of cervical loop cells lead to

A

signal DP - IEE to mature elongate and polarise
signal IEE Dp cells to mature
DP = odontoblasts
IEE = ameloblasts

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6
Q

what does the odontoblasts form

A

predestine then dentine

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7
Q

what does the Amelobalsts gove rise to

A

enamel

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8
Q

what is some evidence of IEE cells synthesising enamel proteins

A

IEE cells more columnar and nucleus toward stratum intermedium - diff begins

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9
Q

where si the first place for predestine to be placed

A

at cusp

clos to enamel knot

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10
Q

how does the enamel knot affect cusp

A

growth factors

differneiation

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11
Q

once the dentine is made what happens

A

signal amelobasts to become sec and lay down enamel

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12
Q

what does epi do at cervical loop

A

proliferate

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13
Q

what is cervical loop largely imp for

A

root development

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14
Q

what are the cells found at the cervucal loop

A

IEE and ecto mesenchyme - yet to dif

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15
Q

what does the ecto mesenchyme signal

A

induces the limited proliferation of IEE

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16
Q

what signals from the ecto mesenchyme

A

BMP
WNT
FGF

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17
Q

what is sequence fro cervical loop diff

A

DP to IEE - control div
See to DP - induce pap cells to mature
DP to IEE - induce IEE to mature
dentine to IEE - dentine signals start of enamel sec

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18
Q

what does IEE diff into

A

ameloblasts

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19
Q

what do ameobalsts then do

A

signal to condense mesenchyme and these will start to diff into odontoblasts

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20
Q

what causes chines in matrix

A

laminin
CS-PG
enamel proteins

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21
Q

what is the process of maturing odontoblast

A 
ameloblast diff first 
ectomesenchyme diff under layer
ameloblast signal to diff layer
nucleus move 
matrix laid down
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22
Q

before mineralisation of matrix takes place what happens

A

a lag phase before

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23
Q

what are some diff layers of dentine

A

mantle
granular
hyaline

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24
Q

what is matrix mostly prod by

A

collagen

25
Q

what cells can be seen in developing tooth in late bell stage

A

dental papilla
functioning odontoblasts
pre-ameloblasts
- predestine formed = ameloblast= enamel

26
Q

what is the lifecycle outline of an ameloblast

A 
IEE start to diff 
reverse polarity - nun move
enamel se cells
maturation 
regress height
27
Q

what is the stages in ameloblast life

A 
pre sec
sec
transition
maturation
post maturation
28
Q

what si the pre sec stage in ameloblast life

A

cytodiff
morphodiff
resorption basal lamina
epitomes interctaion

29
Q

what is the sec stage in ameloblast life

A 
initial layer enamel 
matrix sec
initiation
mineralisation
degrade matrix
30
Q

what is the transition stage in ameloblast stage

A

ameloblasts shorten die
reform basal lamina
cessation of matrix form
matrix degrade

31
Q

what is the maturation stage of ameloblast

A

final degradation and withdraw matrix

crystal growth

32
Q

what si the post maturation stage of ameloblast life

A

enamel organ degen
enamel cover established
eruption
expo oral cav

33
Q

what is developing enamel

A

ameloblasts sec enamel

min and laid down

34
Q

what is predentine

A

organic matrix that makes up dentine before it has calcified

35
Q

what is in the organic matrix

A 
collagens 1,3,5,6
proteoglycans - decor
glycoproteins - osteonectin
phosphoproteins - octeocalcin 
GF
lipids
36
Q

what is dentine

A

mineralised predestine

37
Q

how is predestine mineralised to get dentine

A

1st layers matrix unmineralised when thick are min at same rate of formation
mineral depo
form primar dentien

38
Q

what depo minerals in dentine form

A

odontoblasts

39
Q

what controls dentine form

A

odontoblast control all

40
Q

what is basic understanding of enamel

A

diff proteins form dentine

41
Q

what are he two groups of enamel

A

amelogenins

enamelins

42
Q

what are amelogenisn

A

multiple slice variants maj

43
Q

what are enamelins

A

make up minority

44
Q

when does morphogenesis

A

late cap stage and early bell stage

45
Q

what is morphogenesis

A

rapid growth
cell divIEE
tooth shape determined

46
Q

how is the shape determined

A

switch on and off sp transcription factors

47
Q

whereis Shh found

A

dental epi

48
Q

what does Shh do

A

increases cell proliferation, restriction of expression

49
Q

when does reduced enamel epi from

A

when enamel formation complete

50
Q

what is reduced enamel epi derived from

A

reduced ameloblasts

other remnants of enamel organ - OEE, SR, SI

51
Q

what is the role of reduced enamel epi

A

protect enamel surface (resorption, cementum form)
epi lined path fro eruption
junctional epi

52
Q

what si the secondary dental lamina

A

secessional dental laminae for developing successional teeth

53
Q

what are some abnormalities which can occur at the inanition stage

A

anodontia
supernumerary teeth
micr/macrodontia

54
Q

what is andontia

A

absence of teeth

55
Q

what is supernumerary test

A

extra teeth

56
Q

what is micro/macrodontia

A

miro - small teeth

macro - large teeth

57
Q

what are some abdnomalites that can occur at cap stage

A

dens in dente

fusion and germination

58
Q

what is dens in dentate

A

enamel organ invaginate into dental papilla

slits or gaps

59
Q

what is fusion and germination

A

fusion- 2 roots - 1

germinate 1- 2/3 roots

Developmental Biology (12 decks)

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