TMP-SMX Flashcards
1
Q
What is TMP-SMX MOA
A
Inhibit DNA, RNA, protein production
2
Q
What is bacterias MOR to TMP-SMX
A
gene mutation
3
Q
What is TMP-SMX used to treat
A
Strep Staph MSSA MRSA CA-MRSA H flu M cat E coli Klebssiella Serratia GI pathogens Pneumocystis (carinii) jiroveci
4
Q
What does the body do to TMP-SMX
A
Distributes to everywhere including CSF
Most excreted unchanged in urine
5
Q
What is T1/2 of TMP-SMX
A
10 hrs
6
Q
What are common uses of TMP-SMX
A
DOC - RTI associated with pneumocystis pneumonia (AIDS)
DOC - UTI (e. coli)
GI
7
Q
What are adverse effects of TMP-SMX
A
Sulfa allergy GI upset rash photosensitivity Stevens-johnson and TENs hyperkalemia warfarin hypersensitivity to sulfa or TMP infants preg at term
