Cephalosporins Flashcards
1
Q
What is the cephalosporins MOA
A
interfere cell wall synthesis
2
Q
What is the bacterial MOR to cephalosporins
A
B-lactamase but not as effective as against penicillin
3
Q
What are the types of cephalosporin
A
1st gen - good G +
2nd gen - fair G+ and G-
3rd gen - good G -
4
Q
What are 1st gen cephalosporins
A
Cephalexin
Cefazolin
- skin and bone infections
- UTI
5
Q
What are 2nd gen cephalosporins
A
Cefuroxime Cefoxitin - CAP - sinusitis - AECB - otitis media - UTI
6
Q
What are the 1st gen cephalosporins good at treating
A
strep (no pneumonia)
staph
EKP
7
Q
What are the 2nd gen cephalosporins good at treating
A
staph strep G - EKP anaerobes clostridium
8
Q
What are 3rd/4th gen cephalosporins
A
Cefpodoxime Ceftriaxone + (Vancomyocin) - 1-2g IV 24hr - Meningitis - 2g IV q12hr Ceftazidime
9
Q
what are 3rd/4th gen cephalosporins good at treating
A
staph strep G - EKP ES pseudomonas
10
Q
What are adverse effects for cephalosporins
A
hypersensitive to penicillin and self
diarrhea
platelet dysfunction
neutropenia
