Aminoglycosides Flashcards
1
Q
What is MOA for aminoglycosides
A
Inhibit protein synthesis (30S ribosome)
2
Q
What is bacteria MOR for aminoglycosides
A
closed porin channels
enzymes inactivate
3
Q
What does aminoglycosides treat
A
G -
Pseudomonas
4
Q
what are aminoglycosides
A
Gentamicin
Tobramycin
5
Q
How does aminoglycosides work in body
A
IV
No CSF
renal elimination
6
Q
What are common uses for aminoglycosides
A
used in combo with B-lactam drug
7
Q
What are adverse effects of aminoglycosides
A
Ototoxicity (irreversible)
neprotoxicity (reversible)
Hypersensitive to self
Preg
