clindamycin & metronidazole Flashcards
1
Q
What is MOA clindamycin
A
inhibit protein synthesis (50S)
2
Q
What does clindamycin treat
A
anaerobes
Paracites
PCP
3
Q
How is clindamycin eliminated
A
bile
4
Q
What are common uses for clindamycin
A
anaerobic infections
acne
gardnerella vaginalis
5
Q
What are adverse effects of clindamycin
A
Diarrhea
hypersensitive
hepatic toxicity
pseudomembranous colitis
6
Q
what is MOA metronidazole
A
reactive metabolites that damage DNA
7
Q
What does clindamycin treat
A
G - anaerobes
G+ anaerobes
H pylori
protozoa
8
Q
What are common uses of metronidazole
A
DOC - C difficile colitis
peptic ulcer
vaginosis
chrohns
9
Q
What are types of metronidazole
A
Flagyl IV
- 15 over hr, then 7.5 over 1 hour q6h
10
Q
What are adverse effects of metronidazole
A
Neurologic effects disulfiram w/ alcohol GI upset warfarin hypersensitive
