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Z A Pharm III > Influenza, Anthrax, SARS > Flashcards

Influenza, Anthrax, SARS Flashcards

1
Q

What are the txt for Influenza

A

Oseltamivir (Tamiflu)
Zanamivir (relenza)
Amantadine (Symmetrel)
rimantadine (Flumadine)

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2
Q

When do you use Oseltamivir

A

treat influenza in pts >= 2 weeks old

symptoms less than 2 days

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3
Q

When do you use Oseltamivir prohylaxisly

A

in pts > 1 yr

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4
Q

What is Oseltamivir MOA

A

inhibit virus enzymes

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5
Q

What is efficacy of Oseltamivir if started within 24 hrs of onset

A

reduced symptoms by 1 day

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6
Q

What is efficacy of Oseltamivir if started within 12 hrs of onset

A

reduced illness by 74.6 hrs

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7
Q

What are adverse effects of Oseltamivir

A

Tx:
Insomnia
vertigo
N/V

Prophylax:
HA
fatigue
cough
diahrrea
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8
Q

What is dosage of Oseltamivir

A

75 mg po bid 5 days

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9
Q

When do you use Zanamivir

A

treat influenza in pts >= 7 yrs

symptoms less than 2 days

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10
Q

When do you use Zanamivir prohylaxisly

A

in pts >= 5 yrs

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11
Q

What is Zanamivir MOA

A

inhibit virus enzymes

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12
Q

What is efficacy of Zanamivir

A

relieved symptoms 1.5 days earlier

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13
Q

What are adverse effects of Zanamivir

A

HA
D/N/V
dizziness
bronchospasm

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14
Q

What is dosage of Zanamivir

A

2 inhalations bid x 5

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15
Q

When do you use amantadine or rimantadine

A

Influenza A

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16
Q

What is MOA for amatadine or rimantadine

A

block uncoating of Influenza A virus

17
Q

What are adverse effects of amatadine or rimantadine

A 
Nervousness
anxiety
Nausea
anorexia
behavior changes
18
Q

What is dosing of amatadine or rimantadine

A

100 mg po bid

19
Q

How does SARS spread

A

droplet transmission

20
Q

What is the etiology of SARS

A

SARS-associated coronavirus

21
Q

What is SARS incubation

A

2 - 10 days

22
Q

What are symp of SARS

A 
dry cough
SOB
URT symptoms
Xray confirmed pneumonia
lymphopenia
23
Q

How txt SARS

A

supportive

treat as CAP until confirmed

24
Q

What is anthrax etiology

A

Bacillus antracis

G+ spore

25
Q

What are types of anthrax infection

A

Cutaneous
Gastrointestinal
Inhalation

26
Q

What are txt inhalation anthrax

A

treat 60 days

Cipro or Levo
or
doxycycline

and

clindamycin and/or rifampin

27
Q

How txt anthrax prophylaxis

A

Cipro or Levo or doxycycline

Move to amoxicillin when can

Z A Pharm III (17 decks)

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