Influenza, Anthrax, SARS Flashcards
What are the txt for Influenza
Oseltamivir (Tamiflu)
Zanamivir (relenza)
Amantadine (Symmetrel)
rimantadine (Flumadine)
When do you use Oseltamivir
treat influenza in pts >= 2 weeks old
symptoms less than 2 days
When do you use Oseltamivir prohylaxisly
in pts > 1 yr
What is Oseltamivir MOA
inhibit virus enzymes
What is efficacy of Oseltamivir if started within 24 hrs of onset
reduced symptoms by 1 day
What is efficacy of Oseltamivir if started within 12 hrs of onset
reduced illness by 74.6 hrs
What are adverse effects of Oseltamivir
Tx:
Insomnia
vertigo
N/V
Prophylax: HA fatigue cough diahrrea
What is dosage of Oseltamivir
75 mg po bid 5 days
When do you use Zanamivir
treat influenza in pts >= 7 yrs
symptoms less than 2 days
When do you use Zanamivir prohylaxisly
in pts >= 5 yrs
What is Zanamivir MOA
inhibit virus enzymes
What is efficacy of Zanamivir
relieved symptoms 1.5 days earlier
What are adverse effects of Zanamivir
HA
D/N/V
dizziness
bronchospasm
What is dosage of Zanamivir
2 inhalations bid x 5
When do you use amantadine or rimantadine
Influenza A
What is MOA for amatadine or rimantadine
block uncoating of Influenza A virus
What are adverse effects of amatadine or rimantadine
Nervousness anxiety Nausea anorexia behavior changes
What is dosing of amatadine or rimantadine
100 mg po bid
How does SARS spread
droplet transmission
What is the etiology of SARS
SARS-associated coronavirus
What is SARS incubation
2 - 10 days
What are symp of SARS
dry cough SOB URT symptoms Xray confirmed pneumonia lymphopenia
How txt SARS
supportive
treat as CAP until confirmed
What is anthrax etiology
Bacillus antracis
G+ spore
What are types of anthrax infection
Cutaneous
Gastrointestinal
Inhalation
What are txt inhalation anthrax
treat 60 days
Cipro or Levo
or
doxycycline
and
clindamycin and/or rifampin
How txt anthrax prophylaxis
Cipro or Levo or doxycycline
Move to amoxicillin when can
