Macrolides Flashcards
What is MOA for macrolides
inhibit RNA protein synthesis (50S)
What is bacterias MOR for macrolides
altered target
drug efflux
What are the types of macrolides
Erythromycin
Clarithromycin
Azithromycin
- 500 mg 1 day then 250 mg qd 4 days
What does erythromycin treat
Strep Staph G - Clostridium atypical pneum bordetella pertussis treponema pallidum ricettsia
What does body do to erythromycin
25% bioavailable
No CNS or CSF
Excreted bile
What are common uses of erythromycin
DOC - bordetella pertussis
What are adverse effects of erythromycin
N/V/D
hearing loss
QT prolong
warfarin and other drugs
What does clarithromycin treat
same as erythromycin
M. A. C.
borrelia burgdorferi
babesia microti
What does body do to clarithromycin
50% bioavailable
alverolar macrophages
excrete urine
What are adverse effects of clarithromycin
warfarin and other drugs
What does azithromycin treat
same as erythromycin
atypicals
STI: chlamydia, ureaplasma, gonorrhea
treponema pallidum
What are common uses of azithromycin
STI
URI
CAP
What are adverse effects azithromycin
D/N/V
