tissue injury and repair

Question 1

describe tissue regeneration

Answer 1

the growth of cells and tissues to replace lost structures

Question 2

describe tissue repair

Answer 2

a combination of regeneration and scar formation

Question 3

sequence of healing?

Answer 3

inflammation –> angiogenesis / neovascularization –> migration and proliferation of parenchymal cells and fibroblasts –> scar formation –> connective tissue remodelling

Question 4

local factors that may affect wound healing?

Answer 4

size, location, type (infectious, necrotic, traumatic), infections, mechanical forces, foreign bodies

Question 5

systemic factors that delay wound healing?

Answer 5

nutritional status metabolic status e.g. diabetes, circulatory / vascular status, hormones

Question 6

what causes an hypertrophic scar

Answer 6

excessive collagen accumulation

Question 7

what is a bed sore / pressure sore?

Answer 7

area of unrelieved pressure over a defined area, resulting in ischaemia, necrosis and cell death