Tissue Healing

Question 1

Types of tissue repair

Answer 1

1. Resolution - rapid healing of mild injury (epithelial cells regenerate without incident)
2. Tissue regeneration - specialised tissue is replaced by the proliferation of surrounding undamaged areas
3. Connective tissue repair - lost tissue is replaced by granulation tissue which matures to form scar tissue

Question 2

Timeline for connective tissue repair

Answer 2

Bleeding - hours
Inflammation - weeks (changes in blood flow, phagocytosis, lymphatic drainage)
Proliferation - days>months (start to form granulation tissue, plasma proteins leak into tissue, collagen synthesis)
Remodelling - weeks>months (begins at 3 weeks, continuous remodelling of scar tissue)

Question 3

Factors that affect wound healing

Answer 3

• Nature of injury
• Site of injury
• Temperature
• Drugs (steroids, NSAIDs)
• Movement -/+
• Infection
• Foreign bodies