THYROID DISORDERS Flashcards
what is hyperthyroidism?
-hyperactivity of the thyroid gland
- a form of thyrotoxicosis and both usually occur together.
what is thyrotoxicosis
inappropriately high tissue thyroid levels of t4, t3, or both
what is grave’s disease?
-an autoimmune disease of unknown etiology
-marked by diffuse thyroid enlargement and excessive thyroid hormone secretion
marked by diffuse thyroid enlargement and excessive thyroid hormone secretion
Grave’s Disease
most common type of hyperthyroidism
Grave’s disease
grave’s disease more common in what gender?
more common in women aging 20 to 40 years
etiology of hyperthyroidism
-insufficient iodine supply
- infections
- smoking
- stressful life events
-abnormally high antibodies
abnormally high antibodies cause
creating false signals to the TSH receptors, increasing T3 & T4 release
clinical manifestations of hyperthyroidism
-palpable thyroid gland (goiter)
- bruits heard on the thyroid gland due to increased blood supply
-exopthalmos
-excessive sweating
- heat intolerance
- tachycardia
- tremors
What is the complication of hyperthyroidism?
Thyrotoxic crisis
What is thyrotoxic crisis?
-aka as thyroid storm
- an intensification of all hyperthyroid manifestations
- a rare yet-life threatening condition
Thyrotoxic crisis can happen to:
happens to patients with pre-existing hyperthyroidism, severe tachycardia, heart failure, shock, seizures, delirium
Diagnosis of hyperthyroidism
-Thyroid stimulating hormone test
- T4 test
- Radioactive Iodine Uptake Test
The purpose of thyroid-stimulating hormone test
-decreased TSH levels in positive patient
- an early warning system
T4 test role
-the main form of thyroid hormone
- more accurate when checked with TSH
Radioactive Iodine Uptake Test role
differentiate grave’s disease from other forms of thyroiditis
What are the antithyroid medications?
- thionamides
- iodine
- beta-adrenergic blockers
- propanolol (inderal)
- atenolol
the first-line antithyroid medication
thionamides
mechanism of action of thionamides
inhibit the synthesis of thyroid hormones
this drug is continued for 6 months to 2 years
thionamides
examples of thionamide drug
- propylthiouracil
- carbimazole
- methimazole
iodine drug role in hyperthyroidism
-used with other antithyroid medications for thyroidectomy
iodine mechanism of action
rapidly inhibits synthesis of T3 and T4 and blocks the release of these hormones
through the use of iodine the surgery makes it much safer, why?
decreases the vascularity of the thyroid gland which makes surgery safer
Iodine example drug
-lugol’s solution
- potassium iodide (KI)
- tablets
- saturated solution of potassium iodide (SSKI)